A new asymmetric synthesis of the anti-tumor alkaloid (R)-(+)-Crispine A

Steven M. Allin, Sean N. Gaskell, Joannah M. R. Towler, Philip C. Bulman Page, Basu Saha, Michael J. McKenzie, William P. Martin

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.
Original languageEnglish
Pages (from-to)8972-8975
Number of pages4
JournalThe Journal of Organic Chemistry
Volume72
Issue number23
DOIs
Publication statusPublished - 2007

Keywords

  • ACYLIMINIUM ION CYCLIZATION
  • (+/-)-CRISPINE-A
  • ALPHA-AMIDOALKYLATION REACTIONS
  • DERIVATIVES
  • ENANTIOMERS
  • PYRROLOISOQUINOLINE RING-SYSTEM
  • FACILE
  • STEREOSELECTIVE SYNTHESIS
  • ENANTIOSELECTIVE SYNTHESIS

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