TY - JOUR
T1 - A new paradigm in N-heterocyclic carbenoid ligands
AU - Bulman Page, Philip C.
AU - Buckley, Benjamin R.
AU - Christie, Steven D. R.
AU - Edgar, Mark
AU - Poulton, Andrew M.
AU - Elsegood, Mark R. J.
AU - McKee, Vickie
PY - 2005
Y1 - 2005
N2 - We report a new class of very readily prepared chiral N-heterocyclic carbenoid ligand that also contains two different types of chirality: an asymmetric centre and an atropoisomeric unit, but contained in two separate N-substituents, such that both can easily be varied. In addition to its simplicity and flexibility, this approach has potential advantages over systems containing only atropoisomeric units, because the inclusion of an additional fixed asymmetric centre means that the atropoisomers are diastereoisomers and therefore chemically distinct entities. Complexation to a metal centre increases the barrier to rotation in the atropoisomeric unit so that the two diastercoisomers may be separable by simple methods such as standard chromatography. In addition, a novel cis-substituted palladium complex has been characterised by X-ray crystallography. (c) 2005 Elsevier B.V. All rights reserved.
AB - We report a new class of very readily prepared chiral N-heterocyclic carbenoid ligand that also contains two different types of chirality: an asymmetric centre and an atropoisomeric unit, but contained in two separate N-substituents, such that both can easily be varied. In addition to its simplicity and flexibility, this approach has potential advantages over systems containing only atropoisomeric units, because the inclusion of an additional fixed asymmetric centre means that the atropoisomers are diastereoisomers and therefore chemically distinct entities. Complexation to a metal centre increases the barrier to rotation in the atropoisomeric unit so that the two diastercoisomers may be separable by simple methods such as standard chromatography. In addition, a novel cis-substituted palladium complex has been characterised by X-ray crystallography. (c) 2005 Elsevier B.V. All rights reserved.
U2 - 10.1016/j.jorganchem.2005.09.015
DO - 10.1016/j.jorganchem.2005.09.015
M3 - Article
VL - 690
SP - 6210
EP - 6216
JO - Journal of Organometallic Chemistry
JF - Journal of Organometallic Chemistry
SN - 0022-328X
IS - 24-25
ER -