A new role for Ran in ensuring precise duplication of chromosomal DNA

Research output: Contribution to journalArticlepeer-review


To prevent re-replication of DNA, the licensing of replication origins is inhibited in S phase and G2. New work by Yamaguchi et al. (in this issue of Cell) shows that the small GTPase Ran can directly inhibit licensing inside nuclei once CDKs are active late in the cell cycle.
Original languageEnglish
Pages (from-to)2-4
Number of pages3
Issue number1
Publication statusPublished - 4 Apr 2003

Cite this