A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5

Natalie J Prescott; Sheila A Fisher; Andre Franke; Jochen Hampe; Clive M Onnie; Dianne Soars; Richard Bagnall; Muddassar M Mirza; Jeremy Sanderson; Alastair Forbes; John C Mansfield; Cathryn M Lewis; Stefan Schreiber; Christopher G Mathew

doi:10.1053/j.gastro.2007.03.034

A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5

Natalie J Prescott
, Sheila A Fisher
, Andre Franke
, Jochen Hampe
, Clive M Onnie
, Dianne Soars
, Richard Bagnall
, Muddassar M Mirza
, Jeremy Sanderson
, Alastair Forbes
, John C Mansfield
, Cathryn M Lewis
, Stefan Schreiber
, Christopher G Mathew

Research output: Contribution to journal › Article › peer-review

268 Citations (Scopus)

Abstract

A genome-wide association scan of nonsynonymous DNA polymorphisms identified association of a threonine-to-alanine substitution (T300A) in the autophagy-related 16-like gene ATG16L1 with Crohn's disease. We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis.

Original language	English
Pages (from-to)	1665-71
Number of pages	7
Journal	Gastroenterology
Volume	132
Issue number	5
DOIs	https://doi.org/10.1053/j.gastro.2007.03.034
Publication status	Published - May 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adolescent
Adult
Aged
Autophagy
Carrier Proteins
Child
Child, Preschool
Chromosomes, Human, Pair 5
Cohort Studies
Colitis, Ulcerative
Crohn Disease
Epistasis, Genetic
Female
Genetic Predisposition to Disease
Genotype
Great Britain
Humans
Ileitis
Male
Middle Aged
Models, Genetic
Nod2 Signaling Adaptor Protein
Polymorphism, Single Nucleotide
Risk Factors

Access to Document

10.1053/j.gastro.2007.03.034

Cite this

Prescott, N. J., Fisher, S. A., Franke, A., Hampe, J., Onnie, C. M., Soars, D., Bagnall, R., Mirza, M. M., Sanderson, J., Forbes, A., Mansfield, J. C., Lewis, C. M., Schreiber, S., & Mathew, C. G. (2007). A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology, 132(5), 1665-71. https://doi.org/10.1053/j.gastro.2007.03.034

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title = "A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5",

abstract = "A genome-wide association scan of nonsynonymous DNA polymorphisms identified association of a threonine-to-alanine substitution (T300A) in the autophagy-related 16-like gene ATG16L1 with Crohn's disease. We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis.",

keywords = "Adolescent, Adult, Aged, Autophagy, Carrier Proteins, Child, Child, Preschool, Chromosomes, Human, Pair 5, Cohort Studies, Colitis, Ulcerative, Crohn Disease, Epistasis, Genetic, Female, Genetic Predisposition to Disease, Genotype, Great Britain, Humans, Ileitis, Male, Middle Aged, Models, Genetic, Nod2 Signaling Adaptor Protein, Polymorphism, Single Nucleotide, Risk Factors",

author = "Prescott, \{Natalie J\} and Fisher, \{Sheila A\} and Andre Franke and Jochen Hampe and Onnie, \{Clive M\} and Dianne Soars and Richard Bagnall and Mirza, \{Muddassar M\} and Jeremy Sanderson and Alastair Forbes and Mansfield, \{John C\} and Lewis, \{Cathryn M\} and Stefan Schreiber and Mathew, \{Christopher G\}",

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language = "English",

volume = "132",

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Prescott, NJ, Fisher, SA, Franke, A, Hampe, J, Onnie, CM, Soars, D, Bagnall, R, Mirza, MM, Sanderson, J, Forbes, A, Mansfield, JC, Lewis, CM, Schreiber, S & Mathew, CG 2007, 'A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5', Gastroenterology, vol. 132, no. 5, pp. 1665-71. https://doi.org/10.1053/j.gastro.2007.03.034

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T1 - A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5

AU - Prescott, Natalie J

AU - Fisher, Sheila A

AU - Franke, Andre

AU - Hampe, Jochen

AU - Onnie, Clive M

AU - Soars, Dianne

AU - Bagnall, Richard

AU - Mirza, Muddassar M

AU - Sanderson, Jeremy

AU - Forbes, Alastair

AU - Mansfield, John C

AU - Lewis, Cathryn M

AU - Schreiber, Stefan

AU - Mathew, Christopher G

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AB - A genome-wide association scan of nonsynonymous DNA polymorphisms identified association of a threonine-to-alanine substitution (T300A) in the autophagy-related 16-like gene ATG16L1 with Crohn's disease. We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis.

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KW - Adult

KW - Aged

KW - Autophagy

KW - Carrier Proteins

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KW - Child, Preschool

KW - Chromosomes, Human, Pair 5

KW - Cohort Studies

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - Epistasis, Genetic

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Great Britain

KW - Humans

KW - Ileitis

KW - Male

KW - Middle Aged

KW - Models, Genetic

KW - Nod2 Signaling Adaptor Protein

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

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DO - 10.1053/j.gastro.2007.03.034

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