A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets

Ryan A. Hemming, Megan Bell, Liam J. Duffy, Jonathan Bristow, John D. Wallis, Steven M. Allin, Philip C. Bulman Page

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
6 Downloads (Pure)

Abstract

A new, versatile and highly stereoselective approach for the synthesis of non-racemic 3-substituted isoindolin-1-ones is described from a readily available chiral template. The potential of this new protocol is demonstrated through the synthesis of an enantiomerically enriched 3-alkyl N-H isoindolin-1-one target with an e.e. of 98%.
Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalTetrahedron
Volume75
Issue number1
Early online date24 Nov 2018
DOIs
Publication statusPublished - 3 Jan 2019

Keywords

  • Isoindolinone
  • N-Acyliminium
  • Stereoselective synthesis

Cite this