A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Maofeng Jing, Baodian Guo, Haiyang Li, Bo Yang, Haonan Wang, Guanghui Kong, Yao Zhao, Huawei Xu, Yan Wang, Wenwu Ye, Suomeng Dong, Yongli Qiao, Brett M. Tyler, Wenbo Ma, Yuanchao Wang

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.

Original languageEnglish
Article number11685
JournalNature Communications
Volume7
DOIs
Publication statusPublished - 3 Jun 2016

Cite this