A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Maofeng Jing; Baodian Guo; Haiyang Li; Bo Yang; Haonan Wang; Guanghui Kong; Yao Zhao; Huawei Xu; Yan Wang; Wenwu Ye; Suomeng Dong; Yongli Qiao; Brett M. Tyler; Wenbo Ma; Yuanchao Wang

doi:10.1038/ncomms11685

A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Maofeng Jing, Baodian Guo, Haiyang Li, Bo Yang, Haonan Wang, Guanghui Kong, Yao Zhao, Huawei Xu, Yan Wang, Wenwu Ye, Suomeng Dong, Yongli Qiao, Brett M. Tyler, Wenbo Ma, Yuanchao Wang

The Sainsbury Laboratory

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.

Original language	English
Article number	11685
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms11685
Publication status	Published - 3 Jun 2016

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abstract = "Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.",

author = "Maofeng Jing and Baodian Guo and Haiyang Li and Bo Yang and Haonan Wang and Guanghui Kong and Yao Zhao and Huawei Xu and Yan Wang and Wenwu Ye and Suomeng Dong and Yongli Qiao and Tyler, {Brett M.} and Wenbo Ma and Yuanchao Wang",

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T1 - A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

AU - Jing, Maofeng

AU - Guo, Baodian

AU - Li, Haiyang

AU - Yang, Bo

AU - Wang, Haonan

AU - Kong, Guanghui

AU - Zhao, Yao

AU - Xu, Huawei

AU - Wang, Yan

AU - Ye, Wenwu

AU - Dong, Suomeng

AU - Qiao, Yongli

AU - Tyler, Brett M.

AU - Ma, Wenbo

AU - Wang, Yuanchao

PY - 2016/6/3

Y1 - 2016/6/3

N2 - Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.

AB - Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.

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JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

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A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Abstract

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