A preliminary study of the bioavailability of iron- and zinc-glycine chelates

Susan J. Fairweather-Tait; Thomas E. Fox; S. Gabrielle Wharf; Nawalyah A. Ghani

doi:10.1080/02652039209374049

A preliminary study of the bioavailability of iron- and zinc-glycine chelates

Susan J. Fairweather-Tait, Thomas E. Fox, S. Gabrielle Wharf, Nawalyah A. Ghani

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Groups of rats were fed diets containing marginal levels of Fe and Zn as glycine chelates (tradename 'Chelazome', Albion Laboratories, Verona, New Jersey, USA), or the same level of mineral as ferrous sulphate or zinc carbonate. The Fe diets were fed to weanling rats for 4 weeks and the Zn diets to young adult rats for 5 weeks. Blood Hb concentrations were significantly higher in the group fed Fe-chelazome than ferrous sulphate, 149 and 128 g/l respectively (P less than 0.001), but PCV and liver Fe concentrations were similar between the two groups. No difference in plasma Zn, pancreas, testes or femur Zn concentrations were observed between the two Zn groups, indicating that Zn-chelazome has no advantage over zinc carbonate. The results of this preliminary study indicate that Fe-chelazome has a higher bioavailability than ferrous sulphate and merits further study.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Food Additives and Contaminants
Volume	9
Issue number	1
DOIs	https://doi.org/10.1080/02652039209374049
Publication status	Published - 1992

Keywords

Animals
Biological Availability
Carbonates
Chelating Agents
Delayed-Action Preparations
Ferrous Compounds
Glycine
Iron Chelating Agents
Male
Random Allocation
Rats
Rats, Wistar
Spectrophotometry, Atomic
Zinc
Zinc Compounds

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10.1080/02652039209374049

Cite this

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title = "A preliminary study of the bioavailability of iron- and zinc-glycine chelates",

abstract = "Groups of rats were fed diets containing marginal levels of Fe and Zn as glycine chelates (tradename 'Chelazome', Albion Laboratories, Verona, New Jersey, USA), or the same level of mineral as ferrous sulphate or zinc carbonate. The Fe diets were fed to weanling rats for 4 weeks and the Zn diets to young adult rats for 5 weeks. Blood Hb concentrations were significantly higher in the group fed Fe-chelazome than ferrous sulphate, 149 and 128 g/l respectively (P less than 0.001), but PCV and liver Fe concentrations were similar between the two groups. No difference in plasma Zn, pancreas, testes or femur Zn concentrations were observed between the two Zn groups, indicating that Zn-chelazome has no advantage over zinc carbonate. The results of this preliminary study indicate that Fe-chelazome has a higher bioavailability than ferrous sulphate and merits further study.",

keywords = "Animals, Biological Availability, Carbonates, Chelating Agents, Delayed-Action Preparations, Ferrous Compounds, Glycine, Iron Chelating Agents, Male, Random Allocation, Rats, Rats, Wistar, Spectrophotometry, Atomic, Zinc, Zinc Compounds",

author = "Fairweather-Tait, {Susan J.} and Fox, {Thomas E.} and Wharf, {S. Gabrielle} and Ghani, {Nawalyah A.}",

year = "1992",

doi = "10.1080/02652039209374049",

language = "English",

volume = "9",

pages = "97--101",

journal = "Food Additives and Contaminants",

issn = "0265-203X",

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TY - JOUR

T1 - A preliminary study of the bioavailability of iron- and zinc-glycine chelates

AU - Fairweather-Tait, Susan J.

AU - Fox, Thomas E.

AU - Wharf, S. Gabrielle

AU - Ghani, Nawalyah A.

PY - 1992

Y1 - 1992

N2 - Groups of rats were fed diets containing marginal levels of Fe and Zn as glycine chelates (tradename 'Chelazome', Albion Laboratories, Verona, New Jersey, USA), or the same level of mineral as ferrous sulphate or zinc carbonate. The Fe diets were fed to weanling rats for 4 weeks and the Zn diets to young adult rats for 5 weeks. Blood Hb concentrations were significantly higher in the group fed Fe-chelazome than ferrous sulphate, 149 and 128 g/l respectively (P less than 0.001), but PCV and liver Fe concentrations were similar between the two groups. No difference in plasma Zn, pancreas, testes or femur Zn concentrations were observed between the two Zn groups, indicating that Zn-chelazome has no advantage over zinc carbonate. The results of this preliminary study indicate that Fe-chelazome has a higher bioavailability than ferrous sulphate and merits further study.

AB - Groups of rats were fed diets containing marginal levels of Fe and Zn as glycine chelates (tradename 'Chelazome', Albion Laboratories, Verona, New Jersey, USA), or the same level of mineral as ferrous sulphate or zinc carbonate. The Fe diets were fed to weanling rats for 4 weeks and the Zn diets to young adult rats for 5 weeks. Blood Hb concentrations were significantly higher in the group fed Fe-chelazome than ferrous sulphate, 149 and 128 g/l respectively (P less than 0.001), but PCV and liver Fe concentrations were similar between the two groups. No difference in plasma Zn, pancreas, testes or femur Zn concentrations were observed between the two Zn groups, indicating that Zn-chelazome has no advantage over zinc carbonate. The results of this preliminary study indicate that Fe-chelazome has a higher bioavailability than ferrous sulphate and merits further study.

KW - Animals

KW - Biological Availability

KW - Carbonates

KW - Chelating Agents

KW - Delayed-Action Preparations

KW - Ferrous Compounds

KW - Glycine

KW - Iron Chelating Agents

KW - Male

KW - Random Allocation

KW - Rats

KW - Rats, Wistar

KW - Spectrophotometry, Atomic

KW - Zinc

KW - Zinc Compounds

U2 - 10.1080/02652039209374049

DO - 10.1080/02652039209374049

M3 - Article

C2 - 1397394

VL - 9

SP - 97

EP - 101

JO - Food Additives and Contaminants

JF - Food Additives and Contaminants

SN - 0265-203X

IS - 1

ER -