A randomized comparison of off-pump and on-pump multivessel coronary-artery bypass surgery

Natasha E Khan, Anthony De Souza, Rebecca Mister, Marcus Flather, Jonathan Clague, Simon Davies, Peter Collins, Duolao Wang, Ulrich Sigwart, John Pepper

Research output: Contribution to journalArticlepeer-review

500 Citations (Scopus)


The effect of the use of coronary-artery bypass surgery without cardiopulmonary bypass and cardiac arrest ("off pump") on graft patency remains uncertain. We undertook a prospective, randomized, controlled study to compare graft-patency rates and clinical outcomes in off-pump surgery with conventional, "on-pump" surgery.
Original languageEnglish
Pages (from-to)21-8
Number of pages8
JournalNew England Journal of Medicine
Issue number1
Publication statusPublished - 1 Jan 2004


  • Aged
  • Area Under Curve
  • Cardiopulmonary Bypass
  • Coronary Angiography
  • Coronary Artery Bypass
  • Coronary Disease
  • Coronary Stenosis
  • Coronary Vessels
  • Female
  • Heart-Lung Machine
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Postoperative Complications
  • Prospective Studies
  • Troponin T
  • Vascular Patency

Cite this