Abstract
The increase in incidence and prevalence of neurodegenerative diseases highlights the need for a more comprehensive understanding of how food components may affect neural systems. In particular, flavonoids have been recognized as promising agents capable of influencing different aspects of synaptic plasticity resulting in improvements in memory and learning in both animals and humans. Our previous studies highlight the efficacy of flavonoids in reversing memory impairments in aged rats, yet little is known about the effects of these compounds in healthy animals, particularly with respect to the molecular mechanisms by which flavonoids might alter the underlying synaptic modifications responsible for behavioral changes. We demonstrate that a 3-week intervention with two dietary doses of flavonoids (Dose I: 8.7 mg/day and Dose II: 17.4 mg/day) facilitates spatial memory acquisition and consolidation (24 recall) (p
Original language | English |
---|---|
Pages (from-to) | 335-344 |
Number of pages | 10 |
Journal | Neuropharmacology |
Volume | 79 |
Early online date | 11 Dec 2013 |
DOIs | |
Publication status | Published - Apr 2014 |
Keywords
- BDNF; Flavonoid; Hippocampus; Learning; Memory; NMDR2B; PSA-NCAM