A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome

Susan J van Dijk, Edith J M Feskens, Marieke B Bos, Dianne W M Hoelen, Rik Heijligenberg, Mechteld Grootte Bromhaar, Lisette C P G M de Groot, Jeanne H M de Vries, Michael Müller, Lydia A Afman

Research output: Contribution to journalArticlepeer-review

236 Citations (Scopus)


Changes in dietary fat composition could lower the risk of developing metabolic syndrome. Adipose tissue is an interesting tissue in this respect because of its role in lipid metabolism and inflammation.
Original languageEnglish
Pages (from-to)1656-1664
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Issue number6
Publication statusPublished - Dec 2009


  • Adiponectin
  • Adipose Tissue
  • Adult
  • Aged
  • Chemokine CCL5
  • Complement C3
  • Fatty Acids
  • Female
  • Gene Expression Profiling
  • Humans
  • Immunohistochemistry
  • Insulin Resistance
  • Lipids
  • Male
  • Metabolic Syndrome X
  • Middle Aged
  • Oligonucleotide Array Sequence Analysis
  • PPAR gamma

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