A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Philip Stephens; Sarah Edkins; Helen Davies; Christopher Greenman; Charles Cox; Chris Hunter; Graham Bignell; Jon Teague; Raffaella Smith; Claire Stevens; Sarah O'Meara; Adrian Parker; Patrick Tarpey; Tim Avis; Andy Barthorpe; Lisa Brackenbury; Gemma Buck; Adam Butler; Jody Clements; Jennifer Cole; Ed Dicks; Ken Edwards; Simon Forbes; Matthew Gorton; Kristian Gray; Kelly Halliday; Rachel Harrison; Katy Hills; Jonathon Hinton; David Jones; Vivienne Kosmidou; Ross Laman; Richard Lugg; Andrew Menzies; Janet Perry; Robert Petty; Keiran Raine; Rebecca Shepherd; Alexandra Small; Helen Solomon; Yvonne Stephens; Calli Tofts; Jennifer Varian; Anthony Webb; Sofie West; Sara Widaa; Andrew Yates; Francis Brasseur; Colin S Cooper; Adrienne M Flanagan; Anthony Green; Maggie Knowles; Suet Y Leung; Leendert H J Looijenga; Bruce Malkowicz; Marco A Pierotti; Bin Teh; Siu T Yuen; Andrew G Nicholson; Sunil Lakhani; Douglas F Easton; Barbara L Weber; Michael R Stratton; P Andrew Futreal; Richard Wooster

doi:10.1038/ng1571

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Philip Stephens, Sarah Edkins, Helen Davies, Christopher Greenman, Charles Cox, Chris Hunter, Graham Bignell, Jon Teague, Raffaella Smith, Claire Stevens, Sarah O'Meara, Adrian Parker, Patrick Tarpey, Tim Avis, Andy Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer ColeEd Dicks, Ken Edwards, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, Rebecca Shepherd, Alexandra Small, Helen Solomon, Yvonne Stephens, Calli Tofts, Jennifer Varian, Anthony Webb, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S Cooper, Adrienne M Flanagan, Anthony Green, Maggie Knowles, Suet Y Leung, Leendert H J Looijenga, Bruce Malkowicz, Marco A Pierotti, Bin Teh, Siu T Yuen, Andrew G Nicholson, Sunil Lakhani, Douglas F Easton, Barbara L Weber, Michael R Stratton, P Andrew Futreal, Richard Wooster

Research output: Contribution to journal › Article › peer-review

292 Citations (Scopus)

Abstract

We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

Original language	English
Pages (from-to)	590-592
Number of pages	3
Journal	Nature Genetics
Volume	37
Issue number	6
DOIs	https://doi.org/10.1038/ng1571
Publication status	Published - 1 Jun 2005

Keywords

Aged
Breast Neoplasms
Carcinoma, Ductal, Breast
DNA Mutational Analysis
Female
Humans
Multigene Family
Mutation
Protein Kinases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng1571

Cite this

Stephens, P., Edkins, S., Davies, H., Greenman, C., Cox, C., Hunter, C., Bignell, G., Teague, J., Smith, R., Stevens, C., O'Meara, S., Parker, A., Tarpey, P., Avis, T., Barthorpe, A., Brackenbury, L., Buck, G., Butler, A., Clements, J., ... Wooster, R. (2005). A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nature Genetics, 37(6), 590-592. https://doi.org/10.1038/ng1571

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abstract = "We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.",

keywords = "Aged, Breast Neoplasms, Carcinoma, Ductal, Breast, DNA Mutational Analysis, Female, Humans, Multigene Family, Mutation, Protein Kinases",

author = "Philip Stephens and Sarah Edkins and Helen Davies and Christopher Greenman and Charles Cox and Chris Hunter and Graham Bignell and Jon Teague and Raffaella Smith and Claire Stevens and Sarah O'Meara and Adrian Parker and Patrick Tarpey and Tim Avis and Andy Barthorpe and Lisa Brackenbury and Gemma Buck and Adam Butler and Jody Clements and Jennifer Cole and Ed Dicks and Ken Edwards and Simon Forbes and Matthew Gorton and Kristian Gray and Kelly Halliday and Rachel Harrison and Katy Hills and Jonathon Hinton and David Jones and Vivienne Kosmidou and Ross Laman and Richard Lugg and Andrew Menzies and Janet Perry and Robert Petty and Keiran Raine and Rebecca Shepherd and Alexandra Small and Helen Solomon and Yvonne Stephens and Calli Tofts and Jennifer Varian and Anthony Webb and Sofie West and Sara Widaa and Andrew Yates and Francis Brasseur and Cooper, {Colin S} and Flanagan, {Adrienne M} and Anthony Green and Maggie Knowles and Leung, {Suet Y} and Looijenga, {Leendert H J} and Bruce Malkowicz and Pierotti, {Marco A} and Bin Teh and Yuen, {Siu T} and Nicholson, {Andrew G} and Sunil Lakhani and Easton, {Douglas F} and Weber, {Barbara L} and Stratton, {Michael R} and Futreal, {P Andrew} and Richard Wooster",

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Stephens, P, Edkins, S, Davies, H, Greenman, C, Cox, C, Hunter, C, Bignell, G, Teague, J, Smith, R, Stevens, C, O'Meara, S, Parker, A, Tarpey, P, Avis, T, Barthorpe, A, Brackenbury, L, Buck, G, Butler, A, Clements, J, Cole, J, Dicks, E, Edwards, K, Forbes, S, Gorton, M, Gray, K, Halliday, K, Harrison, R, Hills, K, Hinton, J, Jones, D, Kosmidou, V, Laman, R, Lugg, R, Menzies, A, Perry, J, Petty, R, Raine, K, Shepherd, R, Small, A, Solomon, H, Stephens, Y, Tofts, C, Varian, J, Webb, A, West, S, Widaa, S, Yates, A, Brasseur, F, Cooper, CS, Flanagan, AM, Green, A, Knowles, M, Leung, SY, Looijenga, LHJ, Malkowicz, B, Pierotti, MA, Teh, B, Yuen, ST, Nicholson, AG, Lakhani, S, Easton, DF, Weber, BL, Stratton, MR, Futreal, PA & Wooster, R 2005, 'A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer', Nature Genetics, vol. 37, no. 6, pp. 590-592. https://doi.org/10.1038/ng1571

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AU - Bignell, Graham

AU - Teague, Jon

AU - Smith, Raffaella

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AU - Menzies, Andrew

AU - Perry, Janet

AU - Petty, Robert

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AU - Shepherd, Rebecca

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AU - Solomon, Helen

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AU - Nicholson, Andrew G

AU - Lakhani, Sunil

AU - Easton, Douglas F

AU - Weber, Barbara L

AU - Stratton, Michael R

AU - Futreal, P Andrew

AU - Wooster, Richard

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N2 - We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

AB - We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

KW - Aged

KW - Breast Neoplasms

KW - Carcinoma, Ductal, Breast

KW - DNA Mutational Analysis

KW - Female

KW - Humans

KW - Multigene Family

KW - Mutation

KW - Protein Kinases

U2 - 10.1038/ng1571

DO - 10.1038/ng1571

M3 - Article

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VL - 37

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JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

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