Abstract
Original language | English |
---|---|
Pages (from-to) | 590-592 |
Number of pages | 3 |
Journal | Nature Genetics |
Volume | 37 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jun 2005 |
Keywords
- Aged
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- DNA Mutational Analysis
- Female
- Humans
- Multigene Family
- Mutation
- Protein Kinases
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A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. / Stephens, Philip; Edkins, Sarah; Davies, Helen; Greenman, Christopher; Cox, Charles; Hunter, Chris; Bignell, Graham; Teague, Jon; Smith, Raffaella; Stevens, Claire; O'Meara, Sarah; Parker, Adrian; Tarpey, Patrick; Avis, Tim; Barthorpe, Andy; Brackenbury, Lisa; Buck, Gemma; Butler, Adam; Clements, Jody; Cole, Jennifer; Dicks, Ed; Edwards, Ken; Forbes, Simon; Gorton, Matthew; Gray, Kristian; Halliday, Kelly; Harrison, Rachel; Hills, Katy; Hinton, Jonathon; Jones, David; Kosmidou, Vivienne; Laman, Ross; Lugg, Richard; Menzies, Andrew; Perry, Janet; Petty, Robert; Raine, Keiran; Shepherd, Rebecca; Small, Alexandra; Solomon, Helen; Stephens, Yvonne; Tofts, Calli; Varian, Jennifer; Webb, Anthony; West, Sofie; Widaa, Sara; Yates, Andrew; Brasseur, Francis; Cooper, Colin S; Flanagan, Adrienne M; Green, Anthony; Knowles, Maggie; Leung, Suet Y; Looijenga, Leendert H J; Malkowicz, Bruce; Pierotti, Marco A; Teh, Bin; Yuen, Siu T; Nicholson, Andrew G; Lakhani, Sunil; Easton, Douglas F; Weber, Barbara L; Stratton, Michael R; Futreal, P Andrew; Wooster, Richard.
In: Nature Genetics, Vol. 37, No. 6, 01.06.2005, p. 590-592.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
AU - Stephens, Philip
AU - Edkins, Sarah
AU - Davies, Helen
AU - Greenman, Christopher
AU - Cox, Charles
AU - Hunter, Chris
AU - Bignell, Graham
AU - Teague, Jon
AU - Smith, Raffaella
AU - Stevens, Claire
AU - O'Meara, Sarah
AU - Parker, Adrian
AU - Tarpey, Patrick
AU - Avis, Tim
AU - Barthorpe, Andy
AU - Brackenbury, Lisa
AU - Buck, Gemma
AU - Butler, Adam
AU - Clements, Jody
AU - Cole, Jennifer
AU - Dicks, Ed
AU - Edwards, Ken
AU - Forbes, Simon
AU - Gorton, Matthew
AU - Gray, Kristian
AU - Halliday, Kelly
AU - Harrison, Rachel
AU - Hills, Katy
AU - Hinton, Jonathon
AU - Jones, David
AU - Kosmidou, Vivienne
AU - Laman, Ross
AU - Lugg, Richard
AU - Menzies, Andrew
AU - Perry, Janet
AU - Petty, Robert
AU - Raine, Keiran
AU - Shepherd, Rebecca
AU - Small, Alexandra
AU - Solomon, Helen
AU - Stephens, Yvonne
AU - Tofts, Calli
AU - Varian, Jennifer
AU - Webb, Anthony
AU - West, Sofie
AU - Widaa, Sara
AU - Yates, Andrew
AU - Brasseur, Francis
AU - Cooper, Colin S
AU - Flanagan, Adrienne M
AU - Green, Anthony
AU - Knowles, Maggie
AU - Leung, Suet Y
AU - Looijenga, Leendert H J
AU - Malkowicz, Bruce
AU - Pierotti, Marco A
AU - Teh, Bin
AU - Yuen, Siu T
AU - Nicholson, Andrew G
AU - Lakhani, Sunil
AU - Easton, Douglas F
AU - Weber, Barbara L
AU - Stratton, Michael R
AU - Futreal, P Andrew
AU - Wooster, Richard
PY - 2005/6/1
Y1 - 2005/6/1
N2 - We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
AB - We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
KW - Aged
KW - Breast Neoplasms
KW - Carcinoma, Ductal, Breast
KW - DNA Mutational Analysis
KW - Female
KW - Humans
KW - Multigene Family
KW - Mutation
KW - Protein Kinases
U2 - 10.1038/ng1571
DO - 10.1038/ng1571
M3 - Article
C2 - 15908952
VL - 37
SP - 590
EP - 592
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 6
ER -