A sequential two meal challenge reveals abnormalities in postprandial TAG but not glucose in men with increasing numbers of metabolic syndrome components

Kim G. Jackson, Charlotte M. Walden, Peter Murray, Adrian M. Smith, Julie A. Lovegrove, Anne-Marie Minihane, Christine M. Williams

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Objective To examine the impact of increasing numbers of metabolic syndrome (MetS) components on postprandial lipaemia. Methods Healthy men (n = 112) underwent a sequential meal postprandial investigation, in which blood samples were taken at regular intervals after a test breakfast (0 min) and lunch (330 min). Lipids, glucose and insulin were measured in the fasting sample, with triacylglycerol (TAG), non-esterified fatty acids and glucose analysed in the postprandial samples. Results Subjects were grouped according to the number of MetS components regardless of the combinations of components (0/1, 2, 3 and 4/5). As expected, there was a trend for an increase in body mass index, blood pressure, fasting TAG, glucose and insulin, and a decrease in fasting high-density lipoprotein cholesterol with increasing numbers of MetS components (P = 0.0004). A similar trend was observed for the summary measures of the postprandial TAG and glucose responses. For TAG, the area under the curve (AUC) and maximum concentration (max C) were significantly greater in men with =3 than
Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalAtherosclerosis
Volume220
Issue number1
DOIs
Publication statusPublished - Jan 2012

Cite this