A short preparation of an advanced intermediate for lactacystin synthesis: The complete carbon skeleton of clasto-lactacystin dihydroxyacid

P. C. B. Bulman Page, D. C. Leach, C. M. Hayman, A. S. Hamzah, S. M. Allin, V. McKee

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

An advanced intermediate 22 for lactacystin Synthesis, containing the full carbon skeleton of the pyrrolidinone component, has been achieved in four steps from a protected glycine ester.
Original languageEnglish
Pages (from-to)1025-1027
Number of pages3
JournalSynlett
Issue number7
Publication statusPublished - 2003

Keywords

  • PROTEASOME INHIBITORS
  • Dieckmann
  • lactacystin
  • ROUTE
  • ANALOGS
  • clasto-lactacystin
  • TOOLS
  • D-GLUCOSE
  • EFFICIENT
  • BETA-LACTONE
  • acylation
  • (+)-LACTACYSTIN

Cite this