A simple desymmetrisation approach to unsymmetric N,N'-disubstituted cyclic ureas

Sean P. Bew, Steven D. Bull, Stephen G. Davies, Jason Eames, Anthony D. Baxter, John Mykytiuk

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The bis-enolate derived from 1,3-di-isobutyryl-trans-4,5-tetramethylene- imidazolidin-2-one 8 is unstable and deacylates to afford dianion 11 which can be regioselectively alkylated to afford unsymmetric cyclic urea 17 in good yield. Subsequent deacylation of 17 and methylation on nitrogen affords unsymmetric 1-benzyl-3-methyltrans-4,5-tetramethyleneimidazolidin-2-one 19 in good yield.
Original languageEnglish
Pages (from-to)7143-7146
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number39
DOIs
Publication statusPublished - 24 Sep 1999

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