A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro

L. R. Mikhailova; L. A. Baltina; L. A. Baltina; R. M. Kondratenko; S. A. Nepogodiev; R. A. Field; O. Kunert; M. C. Yin

A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro

L. R. Mikhailova, L. A. Baltina, L. A. Baltina, R. M. Kondratenko, S. A. Nepogodiev, R. A. Field, O. Kunert, M. C. Yin

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.

Original language	English
Pages (from-to)	686-695
Number of pages	10
Journal	Bioorganicheskaia khimiia
Volume	35
Issue number	5
Publication status	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{2f6eeb2b73c14b69954d863528a6cd58,

title = "A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro",

abstract = "A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.",

author = "Mikhailova, {L. R.} and Baltina, {L. A.} and Baltina, {L. A.} and Kondratenko, {R. M.} and Nepogodiev, {S. A.} and Field, {R. A.} and O. Kunert and Yin, {M. C.}",

year = "2009",

language = "English",

volume = "35",

pages = "686--695",

journal = "Bioorganicheskaia khimiia",

issn = "0132-3423",

number = "5",

}

TY - JOUR

T1 - A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro

AU - Mikhailova, L. R.

AU - Baltina, L. A.

AU - Kondratenko, R. M.

AU - Nepogodiev, S. A.

AU - Field, R. A.

AU - Kunert, O.

AU - Yin, M. C.

PY - 2009

Y1 - 2009

N2 - A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.

AB - A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.

UR - http://www.scopus.com/inward/record.url?scp=73349094100&partnerID=8YFLogxK

M3 - Article

C2 - 19915648

AN - SCOPUS:73349094100

VL - 35

SP - 686

EP - 695

JO - Bioorganicheskaia khimiia

JF - Bioorganicheskaia khimiia

SN - 0132-3423

IS - 5

ER -

A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro

Abstract

UN SDGs

Other files and links

Cite this