A small molecule that induces assembly of a four way DNA junction at low temperature

Lesley A. Howell; Zoe A. E. Waller; Richard Bowater; Maria O'Connell; Mark Searcey

doi:10.1039/c1cc12922h

A small molecule that induces assembly of a four way DNA junction at low temperature

Lesley A. Howell, Zoe A. E. Waller, Richard Bowater, Maria O'Connell, Mark Searcey

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29 Citations (Scopus)

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Abstract

Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.

Original language	English
Pages (from-to)	8262-8264
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	29
DOIs	https://doi.org/10.1039/c1cc12922h
Publication status	Published - 2011

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10.1039/c1cc12922h

Cite this

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title = "A small molecule that induces assembly of a four way DNA junction at low temperature",

abstract = "Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.",

author = "Howell, {Lesley A.} and Waller, {Zoe A. E.} and Richard Bowater and Maria O'Connell and Mark Searcey",

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AU - Bowater, Richard

AU - O'Connell, Maria

AU - Searcey, Mark

PY - 2011

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N2 - Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.

AB - Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.

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DO - 10.1039/c1cc12922h

M3 - Article

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JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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