A small molecule that induces assembly of a four way DNA junction at low temperature

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Abstract

Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.
Original languageEnglish
Pages (from-to)8262-8264
Number of pages3
JournalChemical Communications
Volume47
Issue number29
DOIs
Publication statusPublished - 2011

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