A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

Yusuke Iijima, Asami Munakata, Kazuo Shin-ya, A. Ganesan, Takayuki Doi, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Spiruchostatin A, a potent histone deacetylase inhibitor, was efficiently synthesized from (3S,4R)-4-amino-3-hydroxy-5-methylhexanoic acid utilizing solid-phase peptide elongation with d-cysteine, d-alanine, and (E)-3-hydroxy-7-thio-4-heptenoic acid and solution-phase macrolactonization, followed by intramolecular disulfide formation.
Original languageEnglish
Pages (from-to)2970-2972
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number24
DOIs
Publication statusPublished - 17 Jun 2009

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