A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia

Laili Che Rose, Joseph C. Bear, Paul McNaughter, Paul Southern, R. Ben Piggott, Ivan P. Parkin, Sheng Qi, Andrew Mayes

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)
4 Downloads (Pure)

Abstract

An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems.
Original languageEnglish
Article number20271
Number of pages5
JournalScientific Reports
Volume6
Early online date4 Feb 2016
DOIs
Publication statusPublished - Feb 2016

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