A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia

Laili Che Rose; Joseph C. Bear; Paul McNaughter; Paul Southern; R. Ben Piggott; Ivan P. Parkin; Sheng Qi; Andrew Mayes

doi:10.1038/srep20271

A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia

Laili Che Rose, Joseph C. Bear, Paul McNaughter, Paul Southern, R. Ben Piggott, Ivan P. Parkin, Sheng Qi, Andrew Mayes

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

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Abstract

An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems.

Original language	English
Article number	20271
Journal	Scientific Reports
Volume	6
Early online date	4 Feb 2016
DOIs	https://doi.org/10.1038/srep20271
Publication status	Published - Feb 2016

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10.1038/srep20271

Rose et al
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Andrew Mayes
- Andrew.Mayesuea.acuk
- School of Chemistry, Pharmacy and Pharmacology - Emeritus Professor
- Chemistry of Materials and Catalysis - Member
Person: Honorary, Research Group Member
Sheng Qi
- Sheng.Qiuea.acuk
- School of Chemistry, Pharmacy and Pharmacology - Professor of Pharmaceutical Material Science and Technology
- Pharmaceutical Materials and Soft Matter - Member
Person: Research Group Member, Academic, Teaching & Research

Cite this

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title = "A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia",

abstract = "An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems.",

author = "{Che Rose}, Laili and Bear, {Joseph C.} and Paul McNaughter and Paul Southern and Piggott, {R. Ben} and Parkin, {Ivan P.} and Sheng Qi and Andrew Mayes",

note = " This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article{\textquoteright}s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/",

year = "2016",

month = feb,

doi = "10.1038/srep20271",

language = "English",

volume = "6",

journal = "Scientific Reports",

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A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia. / Che Rose, Laili; Bear, Joseph C.; McNaughter, Paul; Southern, Paul; Piggott, R. Ben; Parkin, Ivan P.; Qi, Sheng ; Mayes, Andrew.

In: Scientific Reports, Vol. 6, 20271, 02.2016.

Research output: Contribution to journal › Article › peer-review

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AU - Southern, Paul

AU - Piggott, R. Ben

AU - Parkin, Ivan P.

AU - Qi, Sheng

AU - Mayes, Andrew

N1 - This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PY - 2016/2

Y1 - 2016/2

N2 - An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems.

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A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia

Abstract

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Andrew Mayes

Sheng Qi

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