A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

Darren Gibson; Steven W. Homans; Robert A. Field

doi:10.1016/j.tetasy.2009.02.021

A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

Darren Gibson, Steven W. Homans, Robert A. Field

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.

Original language	English
Pages (from-to)	730-732
Number of pages	3
Journal	Tetrahedron Asymmetry
Volume	20
Issue number	6-8
DOIs	https://doi.org/10.1016/j.tetasy.2009.02.021
Publication status	Published - 7 May 2009

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title = "A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin",

abstract = "Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.",

author = "Darren Gibson and Homans, {Steven W.} and Field, {Robert A.}",

note = "Funding Information: These studies were supported by the BBSRC. We thank the EPSRC National Mass Spectrometry Service Centre, Swansea, for invaluable support.",

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AU - Gibson, Darren

AU - Homans, Steven W.

AU - Field, Robert A.

N1 - Funding Information: These studies were supported by the BBSRC. We thank the EPSRC National Mass Spectrometry Service Centre, Swansea, for invaluable support.

PY - 2009/5/7

Y1 - 2009/5/7

N2 - Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.

AB - Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.

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M3 - Article

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EP - 732

JO - Tetrahedron: Asymmetry

JF - Tetrahedron: Asymmetry

SN - 0957-4166

IS - 6-8

ER -

A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

Abstract

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