A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

Darren Gibson; Steven W. Homans; Robert A. Field

doi:10.1016/j.tetasy.2009.02.021

A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

Darren Gibson
, Steven W. Homans
, Robert A. Field

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.

Original language	English
Pages (from-to)	730-732
Number of pages	3
Journal	Tetrahedron Asymmetry
Volume	20
Issue number	6-8
DOIs	https://doi.org/10.1016/j.tetasy.2009.02.021
Publication status	Published - 7 May 2009

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@article{8933d790747847ec92fb17376f6bb77c,

title = "A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin",

abstract = "Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10\% overall yield.",

author = "Darren Gibson and Homans, \{Steven W.\} and Field, \{Robert A.\}",

note = "Funding Information: These studies were supported by the BBSRC. We thank the EPSRC National Mass Spectrometry Service Centre, Swansea, for invaluable support.",

year = "2009",

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doi = "10.1016/j.tetasy.2009.02.021",

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journal = "Tetrahedron Asymmetry",

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T1 - A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

AU - Gibson, Darren

AU - Homans, Steven W.

AU - Field, Robert A.

N1 - Funding Information: These studies were supported by the BBSRC. We thank the EPSRC National Mass Spectrometry Service Centre, Swansea, for invaluable support.

PY - 2009/5/7

Y1 - 2009/5/7

N2 - Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.

AB - Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.

UR - https://www.scopus.com/pages/publications/65549162988

U2 - 10.1016/j.tetasy.2009.02.021

DO - 10.1016/j.tetasy.2009.02.021

M3 - Article

AN - SCOPUS:65549162988

SN - 0957-4166

VL - 20

SP - 730

EP - 732

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 6-8

ER -

A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

Abstract

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