TY - JOUR
T1 - A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain α-galactosyltransferases
AU - Brown, Jillian R.
AU - Smith, Terry K.
AU - Ferguson, Michael A. J.
AU - Field, Robert A.
N1 - Funding Information:
We acknowledge support from the Wellcome Trust (Programme Grant to MAJF), the BBSRC (studentship to JRB) and the Zeneca Strategic Research Fund (RAF). MAJF is a Howard Hughes Medical Institute International Research Scholar. Professor J.S. Brimacombe, Dr M.L.S. Gtither, Dr K.P.R. Kartha and Dr T.J. Rutherford are thanked for invaluable advice and assistance.
PY - 1998/8/4
Y1 - 1998/8/4
N2 - A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-α-l,3(Man-α-1,6)-Man-α-O-octyl (1), serves as a substrate for two T. brucei α-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-α-1,2-Gal linkage.
AB - A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-α-l,3(Man-α-1,6)-Man-α-O-octyl (1), serves as a substrate for two T. brucei α-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-α-1,2-Gal linkage.
UR - http://www.scopus.com/inward/record.url?scp=0032483111&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(98)00359-X
DO - 10.1016/S0960-894X(98)00359-X
M3 - Article
C2 - 9873484
AN - SCOPUS:0032483111
VL - 8
SP - 2051
EP - 2054
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
SN - 0960-894X
IS - 15
ER -