A systematic review of non-pharmacological interventions for primary Sjögren’s syndrome

Katie Hackett, Katherine Deane, Victoria Strassheim, Vincent Deary, Julia Newton, Tim Rapley, Wan-Fai Ng

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
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Abstract

The objective of this systematic review was to assess the efficacy of non-pharmacological interventions for the management of primary Sjögren’s syndrome. We searched the following databases from inception to September 2014; Cochrane Database of Systematic Reviews; Medline; Embase; PsychINFO; Cinahl and clinical trials registers. We included randomised controlled trials of any non-pharmacological interventions. Two review authors independently reviewed titles and abstracts against the inclusion/exclusion criteria and independently assessed trial quality and extracted data. 1463 studies were identified of which 17 full text articles were screened and 5 studies were included in the review with a total of 130 participants randomised. The included studies investigated effectiveness of an oral lubricating device for dry mouth, acupuncture for dry mouth, lacrimal punctum plugs for dry eyes and psychodynamic group therapy for coping with symptoms. Overall the studies were of low quality and at high risk of bias. Although one study showed punctum plugs to improve dry eyes it was too small for the findings to be conclusive. Overall we identified no evidence to support any non-pharmacological interventions to improve PSS. The area needs quality large randomised controlled trials that are reported according to CONSORT guidelines and address important issues to patients.
Original languageEnglish
Pages (from-to)2025-2032
Number of pages8
JournalRheumatology
Volume54
Issue number11
Early online date30 Jun 2015
DOIs
Publication statusPublished - Nov 2015

Keywords

  • Sjogren's syndrome
  • Systematic review
  • non-pharmacological interventions
  • rheumatology
  • fatigue
  • dryness
  • pain
  • function

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