A thermoresponsive and magnetic colloid for 3D cell expansion and reconfiguration

Aram Saeed, Nora Francini, Lisa White, James Dixon, Toby Gould, Hassan Rashidi, Racha Cheikh Al Ghanami, Veronika Hruschka, Heinz Redl, Brian R. Saunders, Cameron Alexander, Kevin M. Shakesheff

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)
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Abstract

A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postculture by the simple process of lowering the temperature and applying an external magnetic field. The colloidal gel can be reconfigured with thermal and magnetic stimuli to allow patterning of cells in discrete zones and to control movement of cells within the porous matrix during culture.

Original languageEnglish
Pages (from-to)662–668
Number of pages7
JournalAdvanced Materials
Volume27
Issue number4
Early online date29 Nov 2014
DOIs
Publication statusPublished - 27 Jan 2015

Keywords

  • 3D scaffolds
  • biomaterials
  • magnetic particles
  • stem cells
  • thermoresponsive polymers

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