A Versatile Chiral Pyrrolidine Aldehyde Building-Block for Synthesis and Formal Synthesis of ent-Nakadomarin A

Paul McDermott; Robert A. Stockman; Annabella F. Newton; Philip Magnus

doi:10.1055/s-0029-1219182

A Versatile Chiral Pyrrolidine Aldehyde Building-Block for Synthesis and Formal Synthesis of ent-Nakadomarin A

Paul McDermott, Robert A. Stockman, Annabella F. Newton, Philip Magnus

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A stable, simple to synthesise and versatile chiral aldehyde building-block has been developed, its reactivity in Wittig, Horner-Wadsworth-Emmons and Grignard reactions investigated, and its use is demonstrated in a highly efficient synthesis of an intermediate in Dixon’s synthesis of nakadomarin A.

Original language	English
Pages (from-to)	559-562
Number of pages	4
Journal	Synlett
Issue number	4
DOIs	https://doi.org/10.1055/s-0029-1219182
Publication status	Published - 11 Jan 2010

Keywords

aldehyde - building-block - nakadomarin - manzamine

Access to Document

10.1055/s-0029-1219182

Cite this

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title = "A Versatile Chiral Pyrrolidine Aldehyde Building-Block for Synthesis and Formal Synthesis of ent-Nakadomarin A",

abstract = "A stable, simple to synthesise and versatile chiral aldehyde building-block has been developed, its reactivity in Wittig, Horner-Wadsworth-Emmons and Grignard reactions investigated, and its use is demonstrated in a highly efficient synthesis of an intermediate in Dixon{\textquoteright}s synthesis of nakadomarin A.",

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AU - McDermott, Paul

AU - Stockman, Robert A.

AU - Newton, Annabella F.

AU - Magnus, Philip

PY - 2010/1/11

Y1 - 2010/1/11

N2 - A stable, simple to synthesise and versatile chiral aldehyde building-block has been developed, its reactivity in Wittig, Horner-Wadsworth-Emmons and Grignard reactions investigated, and its use is demonstrated in a highly efficient synthesis of an intermediate in Dixon’s synthesis of nakadomarin A.

AB - A stable, simple to synthesise and versatile chiral aldehyde building-block has been developed, its reactivity in Wittig, Horner-Wadsworth-Emmons and Grignard reactions investigated, and its use is demonstrated in a highly efficient synthesis of an intermediate in Dixon’s synthesis of nakadomarin A.

KW - aldehyde - building-block - nakadomarin - manzamine

U2 - 10.1055/s-0029-1219182

DO - 10.1055/s-0029-1219182

M3 - Article

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