A visual MRI atrophy rating scale for the amyotrophic lateral sclerosis-frontotemporal dementia continuum

Ananthan Ambikairajah, Emma Devenney, Emma Flanagan, Belinda Yew, Eneida Mioshi, Matthew C. Kiernan, John R. Hodges, Michael Hornberger (Lead Author)

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Our objective was to distinguish ALS, ALS-FTD and bvFTD via a novel visual MRI cortical atrophy scale that can be employed in a clinical setting. MRI images of 100 participants (33 ALS, 11 ALS-FTD, 22 bvFTD and 34 controls) were rated in four brain areas: orbitofrontal cortex, anterior temporal pole, anterior cingulate, and motor cortex. Areas were rated on a 5- point Likert scale by two raters blinded to the diagnosis. Results demonstrated that bvFTD patients showed the highest levels of atrophy across all regions, while ALS patients had the lowest atrophy scores. ALS-FTD patients have higher atrophy ratings compared to ALS patients for the motor cortex, anterior cingulate and anterior temporal lobe, with a statistical trend for the orbitofrontal cortex. ALS-FTD patients were not significantly different from bvFTD for any of the brain regions. These findings were confirmed in a post hoc VBM analysis of the same participants. Our study demonstrates that a simple visual MRI rating scale can reliably distinguish ALS, ALS-FTD and bvFTD atrophy patterns in a clinical setting. Motor cortex, anterior cingulate and anterior temporal atrophy emerged as good diagnostic markers for ALS-FTD. Employment of this MRI rating scale can complement clinical diagnostics of patients in the ALS-FTD continuum.

Original languageEnglish
Pages (from-to)226-234
Number of pages9
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume15
Issue number3-4
Early online date18 Feb 2014
DOIs
Publication statusPublished - 2014

Keywords

  • Amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • MRI
  • Visual atrophy rating scale

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