Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus

A B Milsom, C J H Jones, J Goodfellow, M P Frenneaux, J R Peters, P E James

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Abstract

Reduced bioavailability of endothelium-derived nitric oxide is implicated in diabetic macrovascular and microvascular disease. In patients with diabetes, we hypothesised that protein glycosylation can alter nitric oxide binding affinity of haemoglobin and plasma proteins, hence reducing nitric oxide availability and causing an alteration in nitric oxide metabolism.
Original languageEnglish
Pages (from-to)1515-22
Number of pages8
JournalDiabetologia
Volume45
Issue number11
DOIs
Publication statusPublished - Nov 2002

Keywords

  • Adult
  • Age of Onset
  • Biological Availability
  • Blood Glucose
  • Blood Specimen Collection
  • Cholesterol
  • Diabetes Mellitus, Type 1
  • Electron Spin Resonance Spectroscopy
  • Glycosylation
  • Hemoglobin A, Glycosylated
  • Hemoglobins
  • Humans
  • Kinetics
  • Nitrates
  • Nitric Oxide
  • Nitrites
  • Triglycerides

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