Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus

A B Milsom; C J H Jones; J Goodfellow; M P Frenneaux; J R Peters; P E James

doi:10.1007/s00125-002-0956-9

Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus

A B Milsom, C J H Jones, J Goodfellow, M P Frenneaux, J R Peters, P E James

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Reduced bioavailability of endothelium-derived nitric oxide is implicated in diabetic macrovascular and microvascular disease. In patients with diabetes, we hypothesised that protein glycosylation can alter nitric oxide binding affinity of haemoglobin and plasma proteins, hence reducing nitric oxide availability and causing an alteration in nitric oxide metabolism.

Original language	English
Pages (from-to)	1515-22
Number of pages	8
Journal	Diabetologia
Volume	45
Issue number	11
DOIs	https://doi.org/10.1007/s00125-002-0956-9
Publication status	Published - Nov 2002

Keywords

Adult
Age of Onset
Biological Availability
Blood Glucose
Blood Specimen Collection
Cholesterol
Diabetes Mellitus, Type 1
Electron Spin Resonance Spectroscopy
Glycosylation
Hemoglobin A, Glycosylated
Hemoglobins
Humans
Kinetics
Nitrates
Nitric Oxide
Nitrites
Triglycerides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00125-002-0956-9

Cite this

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title = "Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus",

abstract = "Reduced bioavailability of endothelium-derived nitric oxide is implicated in diabetic macrovascular and microvascular disease. In patients with diabetes, we hypothesised that protein glycosylation can alter nitric oxide binding affinity of haemoglobin and plasma proteins, hence reducing nitric oxide availability and causing an alteration in nitric oxide metabolism.",

keywords = "Adult, Age of Onset, Biological Availability, Blood Glucose, Blood Specimen Collection, Cholesterol, Diabetes Mellitus, Type 1, Electron Spin Resonance Spectroscopy, Glycosylation, Hemoglobin A, Glycosylated, Hemoglobins, Humans, Kinetics, Nitrates, Nitric Oxide, Nitrites, Triglycerides",

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AU - Milsom, A B

AU - Jones, C J H

AU - Goodfellow, J

AU - Frenneaux, M P

AU - Peters, J R

AU - James, P E

PY - 2002/11

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N2 - Reduced bioavailability of endothelium-derived nitric oxide is implicated in diabetic macrovascular and microvascular disease. In patients with diabetes, we hypothesised that protein glycosylation can alter nitric oxide binding affinity of haemoglobin and plasma proteins, hence reducing nitric oxide availability and causing an alteration in nitric oxide metabolism.

AB - Reduced bioavailability of endothelium-derived nitric oxide is implicated in diabetic macrovascular and microvascular disease. In patients with diabetes, we hypothesised that protein glycosylation can alter nitric oxide binding affinity of haemoglobin and plasma proteins, hence reducing nitric oxide availability and causing an alteration in nitric oxide metabolism.

KW - Adult

KW - Age of Onset

KW - Biological Availability

KW - Blood Glucose

KW - Blood Specimen Collection

KW - Cholesterol

KW - Diabetes Mellitus, Type 1

KW - Electron Spin Resonance Spectroscopy

KW - Glycosylation

KW - Hemoglobin A, Glycosylated

KW - Hemoglobins

KW - Humans

KW - Kinetics

KW - Nitrates

KW - Nitric Oxide

KW - Nitrites

KW - Triglycerides

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DO - 10.1007/s00125-002-0956-9

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JO - Diabetologia

JF - Diabetologia

SN - 1432-0428

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