Absence of skin sensitivity to oxides of aluminium, silicon, titanium or zirconium in patients with Crohn's disease

J C Lee, S Halpern, D G Lowe, A Forbes, J E Lennard-Jones

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Some metallic compounds, especially of zirconium, can cause cell mediated granulomatous inflammation of the skin. Pigment granules containing compounds of aluminium, silicon, and titanium have been observed within macrophages in the wall of the small intestine in health and in Crohn's disease. Zirconium compounds can be ingested in toothpaste.
Original languageEnglish
Pages (from-to)231-233
Number of pages3
Issue number2
Publication statusPublished - Aug 1996


  • Aluminum Oxide
  • Case-Control Studies
  • Crohn Disease
  • Dermatitis, Contact
  • Female
  • Granuloma, Foreign-Body
  • Humans
  • Intradermal Tests
  • Male
  • Pilot Projects
  • Silicon Dioxide
  • Titanium
  • Zirconium

Cite this