Abundant lipid and protein components of drusen

Lan Wang, Mark E Clark, David K Crossman, Kyoko Kojima, Jeffrey D Messinger, James A Mobley, Christine A Curcio

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217 Citations (Scopus)

Abstract

Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in RPE isolated from non-macular regions of 36 human retinas with grossly normal maculas obtained
Original languageEnglish
Article numbere10329
JournalPLoS One
Volume5
Issue number4
DOIs
Publication statusPublished - 23 Apr 2010

Keywords

  • Aged
  • Aged, 80 and over
  • Apolipoproteins
  • Eye Proteins
  • Female
  • Humans
  • Lipids
  • Macular Degeneration
  • Male
  • Retina
  • Retinal Drusen
  • Retinal Pigment Epithelium

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