Abundant lipid and protein components of drusen

Lan Wang; Mark E. Clark; David K. Crossman; Kyoko Kojima; Jeffrey D. Messinger; James A. Mobley; Christine A. Curcio

doi:10.1371/journal.pone.0010329

Abundant lipid and protein components of drusen

Lan Wang, Mark E. Clark, David K. Crossman, Kyoko Kojima, Jeffrey D. Messinger, James A. Mobley, Christine A. Curcio

Research output: Contribution to journal › Article › peer-review

292 Citations (SciVal)

Abstract

Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in RPE isolated from non-macular regions of 36 human retinas with grossly normal maculas obtained

Original language	English
Article number	e10329
Journal	PLoS One
Volume	5
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0010329
Publication status	Published - 23 Apr 2010

Keywords

Aged
Aged, 80 and over
Apolipoproteins
Eye Proteins
Female
Humans
Lipids
Macular Degeneration
Male
Retina
Retinal Drusen
Retinal Pigment Epithelium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0010329Licence: CC BY

Cite this

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title = "Abundant lipid and protein components of drusen",

abstract = "Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in RPE isolated from non-macular regions of 36 human retinas with grossly normal maculas obtained ",

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AU - Wang, Lan

AU - Clark, Mark E.

AU - Crossman, David K.

AU - Kojima, Kyoko

AU - Messinger, Jeffrey D.

AU - Mobley, James A.

AU - Curcio, Christine A.

N1 - © 2010 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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N2 - Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in RPE isolated from non-macular regions of 36 human retinas with grossly normal maculas obtained

AB - Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in RPE isolated from non-macular regions of 36 human retinas with grossly normal maculas obtained

KW - Aged

KW - Aged, 80 and over

KW - Apolipoproteins

KW - Eye Proteins

KW - Female

KW - Humans

KW - Lipids

KW - Macular Degeneration

KW - Male

KW - Retina

KW - Retinal Drusen

KW - Retinal Pigment Epithelium

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