Acacetin—A simple flavone exhibiting diverse pharmacological activities

Ruchi Badoni Semwal, Deepak Kumar Semwal, Sandra Combrinck, Jeanne Trill, Simon Gibbons, Alvaro Viljoen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Acacetin (5,7-dihydroxy-4-methoxyflavone) is a naturally occurring flavonoid, known to possess numerous pharmacological properties, including neuroprotective, cardioprotective, anticancer, anti-inflammatory, antidiabetic, and antimicrobial activities. The molecule is widespread throughout the Plant Kingdom, but is particularly abundant in the Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae and Malvaceae families. It has been shown to exhibit strong inhibitory effects against glutathione reductase, cyclo-oxygenase, acetylcholinesterase, aldose reductase and xanthine oxidase enzymes. A comprehensive overview of the potential therapeutic applications of acacetin was prepared after collating selected peer-reviewed papers, accessed from online scientific databases, specifically PubMed, Web of Science and Scopus. The mechanism of action, dose forms and structure-activity relationships of the molecule are some of the aspects discussed in the review, to facilitate further research and use of this molecule.
Original languageEnglish
Pages (from-to)56-65
Number of pages10
JournalPhytochemistry Letters
Volume32
Early online date11 May 2019
DOIs
Publication statusPublished - Aug 2019

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