Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

Sicong Tu, Laurie Miller, Olivier Piguet, Michael Hornberger

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Abstract

Effects of thalamic nuclei damage and related white matter tracts on memory performance are still debated. This is particularly evident for the medio-dorsal thalamus which has been less clear in predicting amnesia than anterior thalamus changes. The current study addresses this issue by assessing 7 thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task. Thalamic patients showed selective impairment to delayed recall, but intact recognition memory. Patients also showed accelerated forgetting of contextual details after a 24 h delay, compared to controls. Importantly, the mammillothalamic tract was intact in all patients, which suggests a role for the medio-dorsal nuclei in recall and early consolidation memory processes.
Original languageEnglish
Article number320
Number of pages9
JournalFrontiers in Behavioral Neuroscience
Volume8
DOIs
Publication statusPublished - 15 Sep 2014

Keywords

  • thalamus
  • anterograde memory
  • stroke
  • mammillothalamic tract
  • MRI

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