TY - JOUR
T1 - Acinetobacter baumannii sampled from cattle and pigs represent novel clones
AU - Mateo-Estrada, Valeria
AU - Vali, Leila
AU - Hamouda, Ahmed
AU - Evans, Benjamin A.
AU - Castillo-Ramirez, Santiago
N1 - Funding information: This work was supported by CONACyT Ciencia Básica 2016 (grant no. 284276) and “Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica PAPIIT” (grant no. IN206019) given to S.C.-R. V.M.-E. is a doctoral student from the Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, and she is funded by a CONACYT doctoral fellowship (no. 1005234).
PY - 2022/8/31
Y1 - 2022/8/31
N2 - Acinetobacter baumannii is a very important human pathogen. Nonetheless, we know very little about nonhuman isolates of A. baumannii. Here, we determine the genomic identity of 15 Scottish cattle and pig isolates, as well as their antibiotic and virulence genetic determinants, and compare them with 148 genomes from the main human clinical international clones. Our results demonstrate that cattle and pig isolates represent novel clones well separated from the major international clones. Furthermore, these new clones showed fewer antibiotic resistance genes and may have fewer virulence genes than human clinical isolates.
AB - Acinetobacter baumannii is a very important human pathogen. Nonetheless, we know very little about nonhuman isolates of A. baumannii. Here, we determine the genomic identity of 15 Scottish cattle and pig isolates, as well as their antibiotic and virulence genetic determinants, and compare them with 148 genomes from the main human clinical international clones. Our results demonstrate that cattle and pig isolates represent novel clones well separated from the major international clones. Furthermore, these new clones showed fewer antibiotic resistance genes and may have fewer virulence genes than human clinical isolates.
KW - Acinetobacter baumannii
KW - One Health
KW - animal isolates
KW - antibiotic resistance
KW - bacterial clones
KW - genome epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85137137953&partnerID=8YFLogxK
U2 - 10.1128/spectrum.01289-22
DO - 10.1128/spectrum.01289-22
M3 - Article
SN - 2165-0497
VL - 10
JO - Microbiology Spectrum
JF - Microbiology Spectrum
IS - 4
M1 - e01289-22
ER -