Acinetobacter baumannii sampled from cattle and pigs represent novel clones

Valeria Mateo-Estrada; Leila Vali; Ahmed Hamouda; Benjamin A. Evans; Santiago Castillo-Ramirez

doi:10.1128/spectrum.01289-22

Acinetobacter baumannii sampled from cattle and pigs represent novel clones

Valeria Mateo-Estrada, Leila Vali, Ahmed Hamouda, Benjamin A. Evans, Santiago Castillo-Ramirez

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Abstract

Acinetobacter baumannii is a very important human pathogen. Nonetheless, we know very little about nonhuman isolates of A. baumannii. Here, we determine the genomic identity of 15 Scottish cattle and pig isolates, as well as their antibiotic and virulence genetic determinants, and compare them with 148 genomes from the main human clinical international clones. Our results demonstrate that cattle and pig isolates represent novel clones well separated from the major international clones. Furthermore, these new clones showed fewer antibiotic resistance genes and may have fewer virulence genes than human clinical isolates.

Original language	English
Article number	e01289-22
Journal	Microbiology Spectrum
Volume	10
Issue number	4
Early online date	29 Jun 2022
DOIs	https://doi.org/10.1128/spectrum.01289-22
Publication status	Published - 31 Aug 2022

Keywords

Acinetobacter baumannii
One Health
animal isolates
antibiotic resistance
bacterial clones
genome epidemiology

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10.1128/spectrum.01289-22Licence: CC BY

spectrum.01289-22Final published version, 1.39 MBLicence: CC BY

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title = "Acinetobacter baumannii sampled from cattle and pigs represent novel clones",

abstract = "Acinetobacter baumannii is a very important human pathogen. Nonetheless, we know very little about nonhuman isolates of A. baumannii. Here, we determine the genomic identity of 15 Scottish cattle and pig isolates, as well as their antibiotic and virulence genetic determinants, and compare them with 148 genomes from the main human clinical international clones. Our results demonstrate that cattle and pig isolates represent novel clones well separated from the major international clones. Furthermore, these new clones showed fewer antibiotic resistance genes and may have fewer virulence genes than human clinical isolates.",

keywords = "Acinetobacter baumannii, One Health, animal isolates, antibiotic resistance, bacterial clones, genome epidemiology",

author = "Valeria Mateo-Estrada and Leila Vali and Ahmed Hamouda and Evans, {Benjamin A.} and Santiago Castillo-Ramirez",

note = "Funding information: This work was supported by CONACyT Ciencia B{\'a}sica 2016 (grant no. 284276) and “Programa de Apoyo a Proyectos de Investigaci{\'o}n e Innovaci{\'o}n Tecnol{\'o}gica PAPIIT” (grant no. IN206019) given to S.C.-R. V.M.-E. is a doctoral student from the Programa de Doctorado en Ciencias Biom{\'e}dicas, Universidad Nacional Aut{\'o}noma de M{\'e}xico, and she is funded by a CONACYT doctoral fellowship (no. 1005234).",

year = "2022",

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doi = "10.1128/spectrum.01289-22",

language = "English",

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AU - Mateo-Estrada, Valeria

AU - Vali, Leila

AU - Hamouda, Ahmed

AU - Evans, Benjamin A.

AU - Castillo-Ramirez, Santiago

N1 - Funding information: This work was supported by CONACyT Ciencia Básica 2016 (grant no. 284276) and “Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica PAPIIT” (grant no. IN206019) given to S.C.-R. V.M.-E. is a doctoral student from the Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, and she is funded by a CONACYT doctoral fellowship (no. 1005234).

PY - 2022/8/31

Y1 - 2022/8/31

N2 - Acinetobacter baumannii is a very important human pathogen. Nonetheless, we know very little about nonhuman isolates of A. baumannii. Here, we determine the genomic identity of 15 Scottish cattle and pig isolates, as well as their antibiotic and virulence genetic determinants, and compare them with 148 genomes from the main human clinical international clones. Our results demonstrate that cattle and pig isolates represent novel clones well separated from the major international clones. Furthermore, these new clones showed fewer antibiotic resistance genes and may have fewer virulence genes than human clinical isolates.

AB - Acinetobacter baumannii is a very important human pathogen. Nonetheless, we know very little about nonhuman isolates of A. baumannii. Here, we determine the genomic identity of 15 Scottish cattle and pig isolates, as well as their antibiotic and virulence genetic determinants, and compare them with 148 genomes from the main human clinical international clones. Our results demonstrate that cattle and pig isolates represent novel clones well separated from the major international clones. Furthermore, these new clones showed fewer antibiotic resistance genes and may have fewer virulence genes than human clinical isolates.

KW - Acinetobacter baumannii

KW - One Health

KW - animal isolates

KW - antibiotic resistance

KW - bacterial clones

KW - genome epidemiology

UR - http://www.scopus.com/inward/record.url?scp=85137137953&partnerID=8YFLogxK

U2 - 10.1128/spectrum.01289-22

DO - 10.1128/spectrum.01289-22

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VL - 10

JO - Microbiology Spectrum

JF - Microbiology Spectrum

IS - 4

M1 - e01289-22

ER -

Acinetobacter baumannii sampled from cattle and pigs represent novel clones

Abstract

Keywords

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