Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations

Morwen RM Williams, Benoît Bertrand, Julio Fernandez-Cestau, Zoë AE Waller, Maria A O'Connell, Mark Searcey, Manfred Bochmann

Research output: Contribution to journalArticle

5 Citations (Scopus)
15 Downloads (Pure)

Abstract

(C^N) and (C^N^C) cyclometalated Au(III) represent a highly promising class of potential anticancer agents. We report here the synthesis of seven new cyclometalated Au(III) complexes with five of them bearing an acridine moiety attached via (N^O) or (N^N) chelates, acyclic amino carbenes (AAC) and N-heterocyclic carbenes (NHC). The antiproliferative properties of the different complexes were evaluated in vitro on a panel of cancer cells including leukaemia, lung and breast cancer cells. We observed a trend between the cytotoxicity and the intracellular gold uptake of some representative compounds of the series. Some of the acridine-decorated complexes were demonstrated to interact with ds-DNA using FRET-melting techniques.
Original languageEnglish
Pages (from-to)13523-13534
Number of pages12
JournalDalton Transactions
Volume47
Issue number38
Early online date3 Sep 2018
DOIs
Publication statusPublished - 14 Oct 2018

Cite this