Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response

Mark Bouwens, Lydia A Afman, Michael Müller

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Peripheral blood mononuclear cells (PBMCs) are relatively easily obtainable cells in humans. Gene expression profiles of PBMCs have been shown to reflect the pathological and physiological state of a person. Recently, we showed that the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) has a functional role in human PBMCs during fasting. However, the extent of the role of PPARalpha in human PBMCs remains unclear. In this study, we therefore performed gene expression profiling of PBMCs incubated with the specific PPARalpha ligand WY14,643.
Original languageEnglish
Article number262
JournalBMC Genomics
Volume9
DOIs
Publication statusPublished - 2 Jun 2008

Keywords

  • Amino Acids
  • Fasting
  • Fatty Acids
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Genome, Human
  • Humans
  • Hypolipidemic Agents
  • Leukocytes, Mononuclear
  • Oligonucleotide Array Sequence Analysis
  • PPAR alpha
  • Pyrimidines
  • Response Elements

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