Active modification of host inflammation by Salmonella

Ana Victoria C Pilar, Sarah A Reid-Yu, Colin A Cooper, David T Mulder, Brian K Coombes

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The dampening of host immune responses is a critical aspect of pathogenesis for the enteropathogen Salmonella enterica. Our laboratory has recently described a role for the secreted effector GogB in disruption of NFκB activation and limitation of the host inflammatory response to infection. GogB alters the NFκB pathway by preventing IκB degradation by the host SCF E3 ubiquitin ligase, through an interaction with Skp1 and FBXO22. The prevention of NFκB activation through this interaction dampens the host inflammatory response in the gut, which in turn limits the damage to host tissues during chronic infection. In this addendum, we summarize these recent findings and discuss their implications and impact in the area of host-pathogen interactions.
Original languageEnglish
Pages (from-to)140-5
Number of pages6
JournalGut Microbes
Volume4
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • Animals
  • Bacterial Proteins
  • Disease Models, Animal
  • F-Box Proteins
  • Gastroenteritis
  • Host-Pathogen Interactions
  • Humans
  • I-kappa B Proteins
  • Immune Evasion
  • Models, Biological
  • NF-kappa B
  • S-Phase Kinase-Associated Proteins
  • SKP Cullin F-Box Protein Ligases
  • Salmonella Infections, Animal
  • Salmonella enterica
  • Virulence Factors

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