Active targeting of gold nanoparticles as cancer therapeutics

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Abstract

Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability makes them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.
Original languageEnglish
Pages (from-to)8774-8789
Number of pages16
JournalChemical Society Reviews
Volume49
Issue number23
Early online date22 Oct 2020
DOIs
Publication statusPublished - 7 Dec 2020

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