Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing Enterobacteriaceae

David M. Livermore, Shazad Mushtaq, Marina Warner, Jiancheng Zhang, Sunil Maharjan, Michel Doumith, Neil Woodford

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216 Citations (Scopus)

Abstract

Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum ß-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-ß-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-ß-lactamases.
Original languageEnglish
Pages (from-to)390-394
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 2011

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