Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum ß-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-ß-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-ß-lactamases.
|Number of pages||5|
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - Jan 2011|