Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae

David M. Livermore; Shazad Mushtaq; Marina Warner; Jiancheng Zhang; Sunil Maharjan; Michel Doumith; Neil Woodford

doi:10.1128/AAC.00756-10

Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae

David M. Livermore, Shazad Mushtaq, Marina Warner, Jiancheng Zhang, Sunil Maharjan, Michel Doumith, Neil Woodford

Research output: Contribution to journal › Article › peer-review

246 Citations (Scopus)

Abstract

Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum ß-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-ß-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-ß-lactamases.

Original language	English
Pages (from-to)	390-394
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	1
DOIs	https://doi.org/10.1128/AAC.00756-10
Publication status	Published - Jan 2011

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10.1128/AAC.00756-10

Cite this

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title = "Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae",

abstract = "Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum {\ss}-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-{\ss}-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-{\ss}-lactamases.",

author = "Livermore, {David M.} and Shazad Mushtaq and Marina Warner and Jiancheng Zhang and Sunil Maharjan and Michel Doumith and Neil Woodford",

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journal = "Antimicrobial Agents and Chemotherapy",

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Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae. / Livermore, David M.; Mushtaq, Shazad; Warner, Marina; Zhang, Jiancheng; Maharjan, Sunil; Doumith, Michel; Woodford, Neil.

In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 1, 01.2011, p. 390-394.

Research output: Contribution to journal › Article › peer-review

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AU - Maharjan, Sunil

AU - Doumith, Michel

AU - Woodford, Neil

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AB - Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum ß-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-ß-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-ß-lactamases.

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