Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae

David M. Livermore; Shazad Mushtaq; Marina Warner; Jiancheng Zhang; Sunil Maharjan; Michel Doumith; Neil Woodford

doi:10.1128/AAC.00756-10

Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae

David M. Livermore, Shazad Mushtaq, Marina Warner, Jiancheng Zhang, Sunil Maharjan, Michel Doumith, Neil Woodford

Research output: Contribution to journal › Article › peer-review

256 Citations (Scopus)

Abstract

Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum ß-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-ß-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-ß-lactamases.

Original language	English
Pages (from-to)	390-394
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	1
DOIs	https://doi.org/10.1128/AAC.00756-10
Publication status	Published - Jan 2011

Access to Document

10.1128/AAC.00756-10

Cite this

@article{0f094bd46ac746f4b38178fd47e4e121,

title = "Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae",

abstract = "Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum {\ss}-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-{\ss}-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-{\ss}-lactamases.",

author = "Livermore, {David M.} and Shazad Mushtaq and Marina Warner and Jiancheng Zhang and Sunil Maharjan and Michel Doumith and Neil Woodford",

year = "2011",

month = jan,

doi = "10.1128/AAC.00756-10",

language = "English",

volume = "55",

pages = "390--394",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "1",

}

TY - JOUR

T1 - Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae

AU - Livermore, David M.

AU - Mushtaq, Shazad

AU - Warner, Marina

AU - Zhang, Jiancheng

AU - Maharjan, Sunil

AU - Doumith, Michel

AU - Woodford, Neil

PY - 2011/1

Y1 - 2011/1

N2 - Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum ß-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-ß-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-ß-lactamases.

AB - Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum ß-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-ß-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-ß-lactamases.

U2 - 10.1128/AAC.00756-10

DO - 10.1128/AAC.00756-10

M3 - Article

SN - 0066-4804

VL - 55

SP - 390

EP - 394

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 1

ER -