Activity of BAL30376 (monobactam BAL19764 + BAL29880 + clavulanate) versus Gram-negative bacteria with characterized resistance mechanisms

David M Livermore, Shazad Mushtaq, Marina Warner

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

BAL30376 combines the siderophore monobactam BAL19764 (Syn/PTX 2416) with the bridged monobactam BAL29880 to inhibit AmpC enzymes and with clavulanate to inhibit extended-spectrum β-lactamases (ESBLs). We tested BAL30376 and its components versus isolates and laboratory strains of Enterobacteriaceae and non-fermenters.
Original languageEnglish
Pages (from-to)2382-95
Number of pages14
JournalJournal of Antimicrobial Chemotherapy
Volume65
Issue number11
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Clavulanic Acid
  • Culture Media
  • Drug Resistance, Bacterial
  • Enzyme Inhibitors
  • Gram-Negative Bacteria
  • Humans
  • Microbial Sensitivity Tests
  • Monobactams
  • beta-Lactamases

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