Activity of BAL30376 (monobactam BAL19764 + BAL29880 + clavulanate) versus Gram-negative bacteria with characterized resistance mechanisms

David M Livermore; Shazad Mushtaq; Marina Warner

doi:10.1093/jac/dkq310

Activity of BAL30376 (monobactam BAL19764 + BAL29880 + clavulanate) versus Gram-negative bacteria with characterized resistance mechanisms

David M Livermore, Shazad Mushtaq, Marina Warner

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

BAL30376 combines the siderophore monobactam BAL19764 (Syn/PTX 2416) with the bridged monobactam BAL29880 to inhibit AmpC enzymes and with clavulanate to inhibit extended-spectrum β-lactamases (ESBLs). We tested BAL30376 and its components versus isolates and laboratory strains of Enterobacteriaceae and non-fermenters.

Original language	English
Pages (from-to)	2382-95
Number of pages	14
Journal	Journal of Antimicrobial Chemotherapy
Volume	65
Issue number	11
DOIs	https://doi.org/10.1093/jac/dkq310
Publication status	Published - Nov 2010

Keywords

Anti-Bacterial Agents
Bacterial Proteins
Clavulanic Acid
Culture Media
Drug Resistance, Bacterial
Enzyme Inhibitors
Gram-Negative Bacteria
Humans
Microbial Sensitivity Tests
Monobactams
beta-Lactamases

Access to Document

10.1093/jac/dkq310

Cite this

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abstract = "BAL30376 combines the siderophore monobactam BAL19764 (Syn/PTX 2416) with the bridged monobactam BAL29880 to inhibit AmpC enzymes and with clavulanate to inhibit extended-spectrum β-lactamases (ESBLs). We tested BAL30376 and its components versus isolates and laboratory strains of Enterobacteriaceae and non-fermenters.",

keywords = "Anti-Bacterial Agents, Bacterial Proteins, Clavulanic Acid, Culture Media, Drug Resistance, Bacterial, Enzyme Inhibitors, Gram-Negative Bacteria, Humans, Microbial Sensitivity Tests, Monobactams, beta-Lactamases",

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AU - Mushtaq, Shazad

AU - Warner, Marina

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KW - Anti-Bacterial Agents

KW - Bacterial Proteins

KW - Clavulanic Acid

KW - Culture Media

KW - Drug Resistance, Bacterial

KW - Enzyme Inhibitors

KW - Gram-Negative Bacteria

KW - Humans

KW - Microbial Sensitivity Tests

KW - Monobactams

KW - beta-Lactamases

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DO - 10.1093/jac/dkq310

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