Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes

David M. Livermore, Shazad Mushtaq, Akihiro Morinaka, Takashi Ida, Kazunori Maebashi, Russell Hope

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

ME1071 is a maleic acid that inhibits metallo-β-lactamases (MBLs). We examined its ability to potentiate different carbapenems against MBL-producing Enterobacteriaceae in relation to its inhibition kinetics.
Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Acinetobacter
  • Bacterial Proteins
  • Carbapenems
  • Drug Synergism
  • Enterobacteriaceae
  • Enzyme Inhibitors
  • Humans
  • Maleates
  • Microbial Sensitivity Tests
  • beta-Lactamases

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