Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes

David M. Livermore; Shazad Mushtaq; Akihiro Morinaka; Takashi Ida; Kazunori Maebashi; Russell Hope

doi:10.1093/jac/dks350

Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes

David M. Livermore, Shazad Mushtaq, Akihiro Morinaka, Takashi Ida, Kazunori Maebashi, Russell Hope

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

ME1071 is a maleic acid that inhibits metallo-β-lactamases (MBLs). We examined its ability to potentiate different carbapenems against MBL-producing Enterobacteriaceae in relation to its inhibition kinetics.

Original language	English
Pages (from-to)	153-158
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	68
Issue number	1
DOIs	https://doi.org/10.1093/jac/dks350
Publication status	Published - Jan 2013

Keywords

Acinetobacter
Bacterial Proteins
Carbapenems
Drug Synergism
Enterobacteriaceae
Enzyme Inhibitors
Humans
Maleates
Microbial Sensitivity Tests
beta-Lactamases

Access to Document

10.1093/jac/dks350

Cite this

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title = "Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes",

abstract = "ME1071 is a maleic acid that inhibits metallo-β-lactamases (MBLs). We examined its ability to potentiate different carbapenems against MBL-producing Enterobacteriaceae in relation to its inhibition kinetics.",

keywords = "Acinetobacter, Bacterial Proteins, Carbapenems, Drug Synergism, Enterobacteriaceae, Enzyme Inhibitors, Humans, Maleates, Microbial Sensitivity Tests, beta-Lactamases",

author = "Livermore, {David M.} and Shazad Mushtaq and Akihiro Morinaka and Takashi Ida and Kazunori Maebashi and Russell Hope",

year = "2013",

month = jan,

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language = "English",

volume = "68",

pages = "153--158",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "1",

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Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes. / Livermore, David M.; Mushtaq, Shazad; Morinaka, Akihiro; Ida, Takashi; Maebashi, Kazunori; Hope, Russell.

In: Journal of Antimicrobial Chemotherapy, Vol. 68, No. 1, 01.2013, p. 153-158.

Research output: Contribution to journal › Article › peer-review

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AU - Livermore, David M.

AU - Mushtaq, Shazad

AU - Morinaka, Akihiro

AU - Ida, Takashi

AU - Maebashi, Kazunori

AU - Hope, Russell

PY - 2013/1

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KW - Acinetobacter

KW - Bacterial Proteins

KW - Carbapenems

KW - Drug Synergism

KW - Enterobacteriaceae

KW - Enzyme Inhibitors

KW - Humans

KW - Maleates

KW - Microbial Sensitivity Tests

KW - beta-Lactamases

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DO - 10.1093/jac/dks350

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VL - 68

SP - 153

EP - 158

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

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