TY - JOUR
T1 - Activity of daptomycin against multi-resistant Gram-positive bacteria including enterococci and Staphylococcus aureus resistant to linezolid
AU - Johnson, A. P.
AU - Mushtaq, S.
AU - Warner, M.
AU - Livermore, D. M.
PY - 2004/10
Y1 - 2004/10
N2 - The activity of daptomycin was assessed against 545 isolates of Gram-positive bacteria including enterococci, coagulase-positive and -negative staphylococci, ß-haemolytic streptococci, viridans streptococci and coryneforms. The panel of isolates was biased towards those with resistance to first-line antimicrobial agents and included linezolid-resistant enterococci and Staphylococcus aureus. MICs of daptomycin were =1 mg/l for all the staphylococci, streptococci, and coryneforms, except for two isolates of Corynebacterium aquaticum, for which MICs were 8 mg/l. Daptomycin MICs were =2 and =4 mg/l for Enterococcus faecalis and Enterococcus faecium, respectively.
AB - The activity of daptomycin was assessed against 545 isolates of Gram-positive bacteria including enterococci, coagulase-positive and -negative staphylococci, ß-haemolytic streptococci, viridans streptococci and coryneforms. The panel of isolates was biased towards those with resistance to first-line antimicrobial agents and included linezolid-resistant enterococci and Staphylococcus aureus. MICs of daptomycin were =1 mg/l for all the staphylococci, streptococci, and coryneforms, except for two isolates of Corynebacterium aquaticum, for which MICs were 8 mg/l. Daptomycin MICs were =2 and =4 mg/l for Enterococcus faecalis and Enterococcus faecium, respectively.
U2 - 10.1016/j.ijantimicag.2004.04.006
DO - 10.1016/j.ijantimicag.2004.04.006
M3 - Article
VL - 24
SP - 315
EP - 319
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 4
ER -