Activity of daptomycin against multi-resistant Gram-positive bacteria including enterococci and Staphylococcus aureus resistant to linezolid

A Johnson, S Mushtaq, M Warner, DM Livermore

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38 Citations (Scopus)


The activity of daptomycin was assessed against 545 isolates of Gram-positive bacteria including enterococci, coagulase-positive and -negative staphylococci, ß-haemolytic streptococci, viridans streptococci and coryneforms. The panel of isolates was biased towards those with resistance to first-line antimicrobial agents and included linezolid-resistant enterococci and Staphylococcus aureus. MICs of daptomycin were =1 mg/l for all the staphylococci, streptococci, and coryneforms, except for two isolates of Corynebacterium aquaticum, for which MICs were 8 mg/l. Daptomycin MICs were =2 and =4 mg/l for Enterococcus faecalis and Enterococcus faecium, respectively.
Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Issue number4
Publication statusPublished - Oct 2004

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