Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci

David M. Livermore, Shazad Mushtaq, Marina Warner, Neil Woodford

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Abstract

Background: TR-700 is the active moiety of TR-701 (DA-7157), a new oral/intravenous oxazolidinone prodrug. We examined its activity against linezolid-susceptible and -resistant staphylococci and enterococci.
Methods: MICs were determined by the CLSI agar dilution method.
Results: MICs of TR-700 were tightly clustered around 0.5 mg/L for linezolid-susceptible staphylococci and enterococci compared with 2 mg/L for linezolid. MICs for 52 linezolid-resistant isolates were raised, but only exceeded 4 mg/L for two Enterococcus faecium isolates homozygous for the G2576T 23S rRNA mutation and for one with an unknown mechanism of linezolid resistance.
Conclusions: TR-700 is 4- to 16-fold more active than linezolid and overcame most linezolid resistance in vitro.
Original languageEnglish
Pages (from-to)713-715
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Volume63
Issue number4
DOIs
Publication statusPublished - Apr 2009

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