Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)

Simon Gibbons, Julia Leimkugel, Moyo Oluwatuyi, Michael Heinrich

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34 Citations (Scopus)


In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efflux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efflux mechanisms. Copyright (C) 2003 John Wiley Sons, Ltd.

Original languageEnglish
Pages (from-to)274-275
Number of pages2
JournalPhytotherapy Research
Issue number3
Publication statusPublished - Mar 2003


  • benzo[c]phenanthridine alkaloids
  • chelerythrine
  • efflux
  • MRSA
  • Nor(A)
  • Msr(A)
  • Tet(K)
  • multidrug resistance
  • mdr

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