Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)

Simon Gibbons; Julia Leimkugel; Moyo Oluwatuyi; Michael Heinrich

doi:10.1002/ptr.1112

Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)

Simon Gibbons, Julia Leimkugel, Moyo Oluwatuyi, Michael Heinrich

Research output: Contribution to journal › Article › peer-review

35 Citations (SciVal)

Abstract

In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efflux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efflux mechanisms. Copyright (C) 2003 John Wiley Sons, Ltd.

Original language	English
Pages (from-to)	274-275
Number of pages	2
Journal	Phytotherapy Research
Volume	17
Issue number	3
DOIs	https://doi.org/10.1002/ptr.1112
Publication status	Published - Mar 2003

Keywords

benzo[c]phenanthridine alkaloids
chelerythrine
efflux
MRSA
Nor(A)
Msr(A)
Tet(K)
multidrug resistance
mdr
IN-VITRO

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10.1002/ptr.1112

Cite this

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title = "Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)",

abstract = "In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efflux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efflux mechanisms. Copyright (C) 2003 John Wiley Sons, Ltd.",

keywords = "benzo[c]phenanthridine alkaloids, chelerythrine, efflux, MRSA, Nor(A), Msr(A), Tet(K), multidrug resistance, mdr, IN-VITRO",

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AU - Leimkugel, Julia

AU - Oluwatuyi, Moyo

AU - Heinrich, Michael

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AB - In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efflux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efflux mechanisms. Copyright (C) 2003 John Wiley Sons, Ltd.

KW - benzo[c]phenanthridine alkaloids

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KW - efflux

KW - MRSA

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KW - Msr(A)

KW - Tet(K)

KW - multidrug resistance

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