Projects per year
Abstract
Extracellular matrix (ECM) remodeling by metalloproteinases is crucial during development. The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin type I motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling. The human family includes 19 members. In this study we identified the 19 members of the ADAMTS family in Xenopus laevis and Xenopus tropicalis. Gene identification and a phylogenetic study revealed strong conservation of the ADAMTS family and contributed to a better annotation of the Xenopus genomes. Expression of the entire ADAMTS family was studied from early stages to tadpole stages of Xenopus, and detailed analysis of ADAMTS9 revealed expression in many structures during organogenesis such as neural crest (NC) derivative tissues, the pronephros and the pancreas. Versican, a matrix component substrate of ADAMTS9 shows a similar expression pattern suggesting a role of ADAMTS9 in the remodeling of the ECM in these structures by degradation of versican.
Original language | English |
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Pages (from-to) | 72-81 |
Journal | Gene Expression Patterns |
Volume | 29 |
Early online date | 21 Jun 2018 |
DOIs | |
Publication status | Published - Sept 2018 |
Keywords
- ADAMTS9
- Xenopus laevis
- Xenopus tropicalis
- ECM
- Versican
Profiles
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Dylan Edwards
- Norwich Medical School - Emeritus Professor
- Norwich Institute for Healthy Aging - Member
- Cancer Studies - Member
Person: Honorary, Research Group Member, Research Centre Member
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Grant Wheeler
- School of Biological Sciences - Professor
- Cells and Tissues - Member
- Wheeler Group - Group Leader
Person: Group Lead, Research Group Member, Academic, Teaching & Research
Projects
- 2 Finished
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DevCom - European Initial Training Network on Developmental and Computational Biology
Veenstra, G. & Wheeler, G.
1/09/13 → 31/08/17
Project: Research
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Regulation of neural crest development by transcriptional pausing
Wheeler, G. & Lott, M.
Biotechnology and Biological Sciences Research Council
1/10/11 → 30/09/14
Project: Research