adhesiomeR: A tool for Escherichia coli adhesin classification and analysis

Katarzyna Sidorczuk, Michał Burdukiewicz, Klara Cerk, Joachim Fritscher, Robert A. Kingsley, Peter Schierack, Falk Hildebrand, Rafał Kolenda

Research output: Contribution to journalArticlepeer-review

Abstract

Adhesins are crucial factors in the virulence of bacterial pathogens such as Escherichia coli. However, to date no resources have been dedicated to the detailed analysis of E. coli adhesins. Here, we provide adhesiomeR software that enables characterization of the complete adhesin repertoire, termed the adhesiome. AdhesiomeR incorporates the most comprehensive database of E. coli adhesins and facilitates an extensive analysis of adhesiome. We demonstrate that adhesiomeR achieves 98% accuracy when compared with experimental analyses. Based on analysis of 15,000 E. coli genomes, we define novel adhesiome profiles and clusters, providing a nomenclature for a unified comparison of E. coli adhesiomes.

Original languageEnglish
Article number609
JournalBMC Genomics
Volume25
DOIs
Publication statusPublished - 17 Jun 2024

Keywords

  • Adhesins
  • Adhesiome
  • Adhesion
  • Escherichia coli
  • Fimbriae
  • Pathotype
  • Virulence factor

Cite this