The biochemical investigation of phaeochromocytoma and paraganglioma (PPGL) has seen significant changes over the last fifty years. in large this has meant clinical laboratories have gone from using colorimetric assays for the measurement of adrenaline and noradrenaline, to the measurement of urinary catecholamines and metadrenalines and more latterly the measurement of plasma metadrenalines. Each approach has posed a number of analytical challenges to the clinical laboratorian. Herein is a critical review of the analytical methodologies available for measurement of urinary and plasma metadrenalines.
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|Published - Dec 2014