Advances in the clinical analysis of plasma and urine metadrenalines

D. M. Ellis; J. J. Dutton; A. S. Davison

Advances in the clinical analysis of plasma and urine metadrenalines

D. M. Ellis, J. J. Dutton, A. S. Davison

Norwich Medical School

Research output: Contribution to specialist publication › Article

Abstract

The biochemical investigation of phaeochromocytoma and paraganglioma (PPGL) has seen significant changes over the last fifty years. in large this has meant clinical laboratories have gone from using colorimetric assays for the measurement of adrenaline and noradrenaline, to the measurement of urinary catecholamines and metadrenalines and more latterly the measurement of plasma metadrenalines. Each approach has posed a number of analytical challenges to the clinical laboratorian. Herein is a critical review of the analytical methodologies available for measurement of urinary and plasma metadrenalines.

Original language	English
Pages	22-26
Number of pages	5
Volume	7
No.	4
Specialist publication	Chromatography Today
Publication status	Published - Dec 2014

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https://www.chromatographytoday.com/article/bioanalytical/40/university-of-liverpool/advances-in-the-clinical-analysisnbspof-plasma-and-urine-metadrenalines/1740

Cite this

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abstract = "The biochemical investigation of phaeochromocytoma and paraganglioma (PPGL) has seen significant changes over the last fifty years. in large this has meant clinical laboratories have gone from using colorimetric assays for the measurement of adrenaline and noradrenaline, to the measurement of urinary catecholamines and metadrenalines and more latterly the measurement of plasma metadrenalines. Each approach has posed a number of analytical challenges to the clinical laboratorian. Herein is a critical review of the analytical methodologies available for measurement of urinary and plasma metadrenalines.",

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AU - Dutton, J. J.

AU - Davison, A. S.

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N2 - The biochemical investigation of phaeochromocytoma and paraganglioma (PPGL) has seen significant changes over the last fifty years. in large this has meant clinical laboratories have gone from using colorimetric assays for the measurement of adrenaline and noradrenaline, to the measurement of urinary catecholamines and metadrenalines and more latterly the measurement of plasma metadrenalines. Each approach has posed a number of analytical challenges to the clinical laboratorian. Herein is a critical review of the analytical methodologies available for measurement of urinary and plasma metadrenalines.

AB - The biochemical investigation of phaeochromocytoma and paraganglioma (PPGL) has seen significant changes over the last fifty years. in large this has meant clinical laboratories have gone from using colorimetric assays for the measurement of adrenaline and noradrenaline, to the measurement of urinary catecholamines and metadrenalines and more latterly the measurement of plasma metadrenalines. Each approach has posed a number of analytical challenges to the clinical laboratorian. Herein is a critical review of the analytical methodologies available for measurement of urinary and plasma metadrenalines.

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JO - Chromatography Today

JF - Chromatography Today

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