Advances in triterpene drug discovery

Zoë R. Goddard; Mark Searcey; Anne Osbourn

doi:10.1016/j.tips.2024.10.003

Advances in triterpene drug discovery

Zoë R. Goddard, Mark Searcey, Anne Osbourn

School of Chemistry, Pharmacy and Pharmacology

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Abstract

Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery and optimisation of a new generation of drug leads.

Original language	English
Pages (from-to)	964-968
Number of pages	5
Journal	Trends in Pharmacological Sciences
Volume	45
Issue number	11
Early online date	30 Oct 2024
DOIs	https://doi.org/10.1016/j.tips.2024.10.003
Publication status	Published - Nov 2024

Keywords

Triterpene
Drug discovery
Review
plant natural products
drug discovery
triterpenes
metabolic engineering

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10.1016/j.tips.2024.10.003Licence: CC BY

Goddard_etal_2024_TrendsPSFinal published version, 1.36 MBLicence: CC BY

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title = "Advances in triterpene drug discovery",

abstract = "Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery and optimisation of a new generation of drug leads.",

keywords = "Triterpene, Drug discovery, Review, plant natural products, drug discovery, triterpenes, metabolic engineering",

author = "Goddard, {Zo{\"e} R.} and Mark Searcey and Anne Osbourn",

note = "Acknowledgments: We acknowledge funding from Biotechnology and Biological Sciences Research Council (BBSRC) Follow-on-Fund grant APP4941, Wellcome Discovery Award 227375/Z/23/Z, the BBRSC Institute Strategic Programme Grant {\textquoteleft}Harnessing biosynthesis for sustainable food and health{\textquoteright} (BB/X01097X/1), and the John Innes Foundation.",

year = "2024",

month = nov,

doi = "10.1016/j.tips.2024.10.003",

language = "English",

volume = "45",

pages = "964--968",

journal = "Trends in Pharmacological Sciences",

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T1 - Advances in triterpene drug discovery

AU - Goddard, Zoë R.

AU - Searcey, Mark

AU - Osbourn, Anne

N1 - Acknowledgments: We acknowledge funding from Biotechnology and Biological Sciences Research Council (BBSRC) Follow-on-Fund grant APP4941, Wellcome Discovery Award 227375/Z/23/Z, the BBRSC Institute Strategic Programme Grant ‘Harnessing biosynthesis for sustainable food and health’ (BB/X01097X/1), and the John Innes Foundation.

PY - 2024/11

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N2 - Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery and optimisation of a new generation of drug leads.

AB - Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery and optimisation of a new generation of drug leads.

KW - Triterpene

KW - Drug discovery

KW - Review

KW - plant natural products

KW - drug discovery

KW - triterpenes

KW - metabolic engineering

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U2 - 10.1016/j.tips.2024.10.003

DO - 10.1016/j.tips.2024.10.003

M3 - Article

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EP - 968

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 11

ER -

Advances in triterpene drug discovery

Abstract

Keywords

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