The aetiology of Crohn’s disease is largely unknown, but probably involves a combination of genetic, immunological and environmental factors. This chapter describes the incidence of Crohn’s disease and the methodological approaches used to investigate the aetiology. Exposures which could influence the risk of Crohn’s disease are discussed, including genetics, smoking, habitual diet, the gut microbiota and commonly prescribed medications, including non-steroidal anti-inflammatory drugs and oral contraceptives. An overview of the clinical features of Crohn’s disease is also presented.
|Title of host publication||Crohn's Disease|
|Subtitle of host publication||Current Concepts|
|Editors||Arumugam Rajesh, Rakesh Sinha|
|Number of pages||178|
|Publication status||Published - 2015|