African swine fever virus infection disrupts centrosome assembly and function

Nolween Jouvenet, Thomas Wileman

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

African swine fever virus (ASFV) is a large, enveloped DNA virus that assembles in perinuclear sites located close to the centrosome. It is reported here that the microtubule network becomes disorganized soon after the onset of viral DNA replication and formation of assembly sites. ASFV infection resulted in loss of γ-tubulin and pericentrin at the centrosome; this was due to protein relocalization, but not degradation. ASFV infection also inhibited the ability of the centrosome to nucleate microtubules. The reorganization of microtubules seen in ASFV-infected cells may therefore be mediated by γ-tubulin and pericentrin redistribution, and consequent disruption of centrosome assembly and function.
Original languageEnglish
Pages (from-to)589-594
Number of pages6
JournalJournal of General Virology
Volume86
Issue number3
DOIs
Publication statusPublished - 1 Mar 2005

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