Age at migration and risk of first episode psychosis in England: First epidemiological evidence from the SEPEA study

JB Kirkbride , Y Hameed, C Crane , G Ankireddipalli, O Jenkins , N Kabacs, A Mestatasio, S Pandey , D Ralevic, S Siddabattuni, B Walden, A Zambrana, F Winton, J Perez, D Fowler, PB Jones

Research output: Contribution to conferencePoster

Abstract

Aim: To test whether age-at-migration is associated with risk of first episode psychosis [FEP]

Background: Although migrant populations experience elevated FEP risk compared with the white British population, it is unclear whether age-at-migration to the UK modifies this risk.
Method: Incidence data on all people, aged 16-35 years, presenting with ICD-10 FEP (F10-33) as part of the 3.5-year SEPEA study were obtained. Participants were classified according to age-at-migration (“UK-born, white British”, “UK-born, ethnic minority”, 0-4[infancy], 5-12[childhood], 13-19[adolescence] or 20+ years) and broad ethnic group (non-British white ethnicities; black Caribbean, African & other black ethnicities; Pakistani & Bangladeshi; other Asian ethnicities; other ethnic groups). Poisson regression was used to model FEP incidence by age-at-migration, after adjustment for age and sex, using the 2011 census to estimate person-years at-risk.

Results: We identified 664 participants with FEP over 2.02m person-years. Relative to the UK-born white British group, rates were raised amongst first generation black ethnic groups immigrating during infancy (incidence rate ratio [IRR]: 4.6; 95%CI: 2.6-8.4), childhood (IRR: 6.3; 95%CI: 2.8-14.1) and adolescence (IRR: 4.5; 95%CI: 2.3-8.6), with similar trends observed for non-British white (IRR: 2.2; 95%CI: 1.0-4.9; p=0.055) and Pakistani and Bangladeshi groups (IRR: 3.5; 95%CI: 0.9-14.1; p=0.076) immigrating during childhood. Other Asian immigrants, moving to the UK in adulthood, had lower FEP rates (IRR: 0.2; 95%CI: 0.1-0.9). Rates were elevated amongst UK-born ethnic minorities (IRR: 2.7; 95%CI: 2.1-3.5).

Conclusion: Our data suggested that moving to the UK during childhood was most strongly associated with increased FEP risk; while migration in adulthood did not confer increased risk, UK-born ethnic minority populations experienced elevated rates.
Original languageEnglish
Publication statusPublished - 2014
EventWorld Association of Social Psychiatry Congress (Social Psychiatry: past, present and future) - London, United Kingdom
Duration: 13 Nov 2014 → …

Conference

ConferenceWorld Association of Social Psychiatry Congress (Social Psychiatry: past, present and future)
CountryUnited Kingdom
CityLondon
Period13/11/14 → …

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